Mechanistic Insights of Qingre Jiedu Recipe Based on Network Pharmacology Approach against Heart Failure

Figure 5

Effects of QJ on myocardial inflammatory and fibrosis via PI3K/AKT-IKKs/STAT3 pathway. (a) Western blots assessed the expressions of PI3K, p-AKT, and AKT in HF rats, and QJ could upregulate the expressions of PI3K and p-AKT. (b) Western blot bands of p-IKKα/β, p-NFκB, and IL-6 and their quantitative results in HF rats, and QJ could downregulate the expressions of p-IKKα/β, p-NFκB, and IL-6. (c) Western blot bands of p-STAT3 and MMP-9 and their quantitative results in HF rats, and QJ could downregulate the expressions of p-STAT3 and MMP-9. Data were presented as the mean ± standard error of three independent experiments (N = 3 per group; , ).

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