In Vivo and In Silico Assessment of Diabetes Ameliorating Potentiality and Safety Profile of Gynura procumbens Leaves

Table 7

Activities of gluconeogenic enzymes in the liver of control and experimental rats.

Group	Glucose-6-phosphatase (n moles of Pi liberated/min/mg protein)	Fructose-1,6-diphosphatase (n moles of Pi liberated/min/mg protein)
C	44.968 ± 4.26	33.84 ± 3.51
A	101.94 ± 6.79	347.45 ± 11.54
A + M100	79.73 ± 3.27^∗	62.96 ± 8.18^∗
A + M200	61.98 ± 3.06^∗	44.18 ± 2.24^∗
A + M500	49.76 ± 3.46^∗	35.04 ± 1.72^∗
A + G500	74.74 ± 8.89^∗	70.04 ± 7.69^∗
A + G750	56.44 ± 3.78^∗	50.936 ± 5.54^∗
A + G1000	46.12 ± 3.072^∗	40.146 ± 2.40^∗
M100	47.052 ± 3.51	32.458 ± 3.45
M200	42.516 ± 2.26	30.62 ± 3.12
M500	48.56 ± 2.35	30 ± 0.911
G500	45.84 ± 2.32	33.52 ± 1.85
G750	44.652 ± 3.28	31.64 ± 4.05
G1000	50.22 ± 3.39	31.58 ± 2.03

^∗ indicates a significant difference from the disease group (C = control group, A = alloxan-treated group, M = metformin, A + M = alloxan + metformin, A + G = alloxan + Gynura, and G = G. procumbens).