Pharmacological Mechanism of Shen Huang Chong Ji for Treating Alzheimer’s Disease Based on Network Pharmacology and Experimental Validation

Figure 9

The docking model of quercetin with the top 12 core target genes and apoptosis-related target genes in the topological analysis of AD-related PPI networks. (a-l) Twelve core target genes, including HSP90AA1, AKT1, MAPK1, JUN, RELA, MAPK14, ESR1, FOS, IL-6, MYC, CDKN1A, and RB1, with quercetin. (m-q) Apoptosis-related target genes, including Bcl2, BAX, Caspase-8, Caspase-9, and Caspase-3, with quercetin. (r) The chemical structure and molecular formula of quercetin.

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