Structural and Functional Properties of Activator Protein-1 in Cancer and Inflammation

Table 3

Representative examples of natural compounds analyzed for their anti-inflammatory and anticancer properties by altering cellular pathways in different cell lines.

Flavonoid	Source species	Cell line	Targeted pathway	References
Sophoraflavanone M	Sophora flavescens Ait	Murine macrophage RAW264.7	NF-κB and JNK/AP-1	[50]
Naringenin	Citrus paradisi	A549	JNK/AP-1	[67]
Quercitrin	Fagopyrum tataricum	JB6 P+	AP-1 and MAPK	[68]
Kaempferol	Smilax china	RAW 264.7 macrophages	NF-κB, AP-1, and JAK-STAT	[65]
Orientin	Adonis vernalis	MCF-7	PKCα/ERK/AP-1/STAT3	[64]
Fisetin	Acacia greggii	Human osteosarcoma cells	JNK/ERK/AP-1	[63]
Epicatechin	Acacia catechu L.f.	Mouse primary astrocytes	Nrf2 and AP-1	[69]
Chrysin	Passiflora caerulea	AGS	MMP-9/AP-1/ERK/JNK	[70]
Glabridin	Glycyrrhiza glabra	Huh7 and Sk-Hep-1	NF-κB and AP-1	[71]
Acacetin	Robinia pseudoacacia	A549	NF-κB and AP-1	[72]