Evidence-Based Complementary and Alternative Medicine

Natural Products as a Source for New Leads in Gout Treatment


Publishing date
01 Jan 2020
Status
Closed
Submission deadline
30 Aug 2019

1University of Beira Interior, Covilhã, Portugal

2King Abdulaziz University, Jeddah, Saudi Arabia

This issue is now closed for submissions.
More articles will be published in the near future.

Natural Products as a Source for New Leads in Gout Treatment

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Gout is a common inflammatory arthritis characterized by elevated plasmatic levels of uric acid. Several risk factors were identified, including diets rich in seafood and meat, alcohol consumption, and obesity. In this disease, when uric acid levels in the body increase due to increased formation and/or decreased excretion, the solubility limits of sodium urate are exceeded and precipitation occurs, particularly within joints, synovial fluid, and periarticular tissues. The deposits of urate crystals can initiate attacks of acute painful gouty arthritis which can evolve to chronic gout when permanent erosive joint deformity emerges. The estimated prevalence of this condition is increasing in many developed countries, particularly in men and postmenopausal women. Therefore, preventive and therapeutic strategies have been considered to avoid and treat this disease. In this context, the control of gout has been mainly performed by reducing the inflammation (e.g., with colchicine and nonsteroidal anti-inflammatory drugs), as well as by reducing the uric acid formation (e.g., using alopurinol and febuxostat) and by favouring its excretion (e.g., with probenecid and sulfinpyrazone). However, these approaches only have relative success and can originate several side effects, particularly in chronic use. For these reasons, over the years researchers have been searching for alternative therapeutic strategies, particularly involving the use of natural products.

This special issue aims to collect original research as well as review articles and meta-analysis addressing the use of natural products, as either extracts or isolated compounds, in gout control. Therefore, we kindly invite researchers to contribute manuscripts with in vitro, in vivo, and clinical studies focusing not only on the effects of natural products on the control of uric acid levels, but also on potential treatments to reduce the gouty inflammatory arthritis.

Potential topics include but are not limited to the following:

  • Sources of natural products used in the treatment of gout
  • Isolation and characterization of natural products useful in gout control
  • Natural products which increase uric acid excretion and/or reduce uric acid absorption
  • Natural products with antioxidant and anti-inflammatory effects in gout
  • Natural products which reduce uric acid biosynthesis or enhance its degradation
  • Comparison of natural and synthetic drugs in gout treatment
  • Safety of gout control with natural products
  • Chemical modifications of natural products useful in gout control to improve their efficacy and/or safety

Articles

  • Special Issue
  • - Volume 2020
  • - Article ID 3086106
  • - Research Article

Beneficial Effects of Macroporous Resin Extract of Dendrobium candidum Leaves in Rats with Hyperuricemia Induced by a High-Purine Diet

Xiao-Jing Lou | Yu-Zhi Wang | ... | Su-Hong Chen
  • Special Issue
  • - Volume 2020
  • - Article ID 4501261
  • - Research Article

Optimization of Extraction Conditions of Phytochemical Compounds and Anti-Gout Activity of Euphorbia hirta L. (Ara Tanah) Using Response Surface Methodology and Liquid Chromatography-Mass Spectrometry (LC-MS) Analysis

Fazleen Izzany Abu Bakar | Mohd Fadzelly Abu Bakar | ... | Sri Fatmawati
  • Special Issue
  • - Volume 2020
  • - Article ID 7976130
  • - Review Article

The Impact of Natural Product Dietary Supplements on Patients with Gout: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Juan Yang | Guangxi Li | ... | Brent A. Bauer
  • Special Issue
  • - Volume 2019
  • - Article ID 4936351
  • - Research Article

Study of the Binding Interaction between Wortmannin and Calf Thymus DNA: Multispectroscopic and Molecular Docking Studies

Shiva Mehran | Yousef Rasmi | ... | Zafar Gholinejad
  • Special Issue
  • - Volume 2019
  • - Article ID 9456318
  • - Research Article

A Traditional Clinic Chinese Medicine Prescription Qu-Zhuo-Tong-Bi (QZTB) Alleviates Gouty Arthritis in Model Rats

Huiqing Lv | Jianzhi Chen | ... | Jie Yu
  • Special Issue
  • - Volume 2019
  • - Article ID 5946291
  • - Research Article

Aqueous and Methanol Extracts of Paullinia pinnata (Sapindaceae) Improve Monosodium Urate-Induced Gouty Arthritis in Rat: Analgesic, Anti-Inflammatory, and Antioxidant Effects

Pius Pum Tseuguem | Télesphore Benoît Nguelefack | ... | Sorelle Mbankou Ngassam
  • Special Issue
  • - Volume 2019
  • - Article ID 9896757
  • - Review Article

Effectiveness of Cherries in Reducing Uric Acid and Gout: A Systematic Review

Pei-En Chen | Chia-Yu Liu | ... | Tao-Hsin Tung
  • Special Issue
  • - Volume 2019
  • - Article ID 2969364
  • - Research Article

Suppressive Effect of Huzhentongfeng on Experimental Gouty Arthritis: An In Vivo and In Vitro Study

Zi-cong Wu | Qiang Xue | ... | Zhi-ping Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 9710876
  • - Research Article

Phytochemistry, Antioxidant Activity, Antiproliferative Effect, and Acute Toxicity Testing of Two Moroccan Aristolochia Species

Mohammed Bourhia | Fatima Ezzahra Laasri | ... | Laila Benbacer
Evidence-Based Complementary and Alternative Medicine
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