Evidence-Based Complementary and Alternative Medicine

Tropical Protozoan Diseases: Natural Product Drug Discovery and Development


Publishing date
14 Jun 2013
Status
Published
Submission deadline
12 Apr 2013

1Department of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina

2Facultat de Fármacia, Universitat de Barcelona, Barcelona, Spain

3Núcleo de Investigações Químico-Farmacêuticas (NIQFAR-CCS), Universidade do Vale do Itajaí, Itajaí, SC, Brazil

4Department of Chemistry, The University of Alabama in Huntsville, Huntsville, AL 35899, USA


Tropical Protozoan Diseases: Natural Product Drug Discovery and Development

Description

Chagas disease, human African trypanosomiasis, malaria, and leishmaniasis are tropical protozoan diseases that affect many millions of people worldwide. Currently, there is a lack of effective, safe, and affordable therapies for their treatments. Natural products may serve as novel agents, lead or scaffold for the development into urgently needed efficacious drugs.

We invite authors to submit original research articles and review articles that will contribute to the discovery of natural compounds with high potential against these protozoan parasites. We are particularly interested in articles dealing with in vivo assays and those that look into different mechanisms of action. Potential topics include, but are not limited to:

  • Recent advances in the identification of natural compounds (plants, fungi, or marine organisms) with antiprotozoal activity against Trypanosoma cruzi, T. brucei, Plasmodium falciparum, and Leishmania sp.
  • Identification of specific targets within key metabolic pathways
  • Development of methods of rational drug design
  • Advances in structure-activity relationship studies (SAR and QSAR) of bioactive compounds
  • Optimization of antiprotozoal activity of natural molecules by chemical modifications

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/ecam/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/submit/journals/ecam/proto/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 404250
  • - Editorial

Tropical Protozoan Diseases: Natural Product Drug Discovery and Development

Liliana Muschietti | Roser Vila | ... | William Setzer
  • Special Issue
  • - Volume 2013
  • - Article ID 742476
  • - Research Article

Antimalarial Activity of Cocos nucifera Husk Fibre: Further Studies

J. O. Adebayo | E. A. Balogun | ... | A. U. Krettli
  • Special Issue
  • - Volume 2013
  • - Article ID 945953
  • - Research Article

Trypanocidal Activity of Thioamide-Substituted Imidazoquinolinone: Electrochemical Properties and Biological Effects

Fernanda M. Frank | Alejandra B. Ciccarelli | ... | Maria E. Lombardo
  • Special Issue
  • - Volume 2013
  • - Article ID 874367
  • - Research Article

The Effects of N-Butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide against Leishmania amazonensis Are Mediated by Mitochondrial Dysfunction

Hélito Volpato | Vânia Cristina Desoti | ... | Celso Vataru Nakamura
  • Special Issue
  • - Volume 2013
  • - Article ID 265025
  • - Research Article

Evaluation of Antileishmanial Activity of Selected Brazilian Plants and Identification of the Active Principles

Valdir Cechinel Filho | Christiane Meyre-Silva | ... | Angela Malheiros
  • Special Issue
  • - Volume 2013
  • - Article ID 627898
  • - Research Article

Trypanocidal Activity of Smallanthus sonchifolius: Identification of Active Sesquiterpene Lactones by Bioassay-Guided Fractionation

F. M. Frank | J. Ulloa | ... | L. V. Muschietti
  • Special Issue
  • - Volume 2013
  • - Article ID 163404
  • - Research Article

Natural Sesquiterpene Lactones Induce Oxidative Stress in Leishmania mexicana

Patricia Barrera | Valeria P. Sülsen | ... | Miguel A. Sosa
  • Special Issue
  • - Volume 2013
  • - Article ID 435398
  • - Research Article

Synergistic Effect of Lupenone and Caryophyllene Oxide against Trypanosoma cruzi

Glendy Polanco-Hernández | Fabiola Escalante-Erosa | ... | Luis M. Peña-Rodríguez
  • Special Issue
  • - Volume 2013
  • - Article ID 940531
  • - Research Article

Eupomatenoid-5 Isolated from Leaves of Piper regnellii Induces Apoptosis in Leishmania amazonensis

Francielle Pelegrin Garcia | Danielle Lazarin-Bidóia | ... | Celso Vataru Nakamura
  • Special Issue
  • - Volume 2013
  • - Article ID 279726
  • - Research Article

Eugenia uniflora L. Essential Oil as a Potential Anti-Leishmania Agent: Effects on Leishmania amazonensis and Possible Mechanisms of Action

Klinger Antonio da Franca Rodrigues | Layane Valéria Amorim | ... | Fernando Aécio de Amorim Carvalho
Evidence-Based Complementary and Alternative Medicine
 Journal metrics
Acceptance rate26%
Submission to final decision70 days
Acceptance to publication39 days
CiteScore2.010
Impact Factor1.984
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