Evidence-Based Complementary and Alternative Medicine

Underlying Mechanisms of the Cardioprotective Effects of Natural Products on Endothelial Function and Arteriosclerosis


Publishing date
01 May 2022
Status
Closed
Submission deadline
17 Dec 2021

1Federal University of Grande Dourados, Dourados, Brazil

2Federal University of Mato Grosso do Sul, Campo Grande, Brazil

3Paranaense University, Umuarama, Brazil

4University of La Rochelle, La Rochelle, France

This issue is now closed for submissions.
More articles will be published in the near future.

Underlying Mechanisms of the Cardioprotective Effects of Natural Products on Endothelial Function and Arteriosclerosis

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Arteriosclerosis is the leading cause of mortality in industrialized countries, and it is related to hardening, thickening, and loss of elasticity of the walls of arteries. Currently, there are three main categories of arteriosclerosis: atherosclerosis, Mönckeberg medial calcific sclerosis, and arteriolosclerosis. This process gradually restricts the blood flow to tissues and can lead to severe health risks. The main cause of arteriosclerosis is atherosclerosis, a pathological process involving the endothelium of the tunica media and intima and related to the oxidation of cholesterol followed by a complex inflammatory chain. Atherosclerosis is the primary cause of coronary artery disease and stroke, with multiple genetic and environmental contributions.

Among the therapeutic options available to treat arteriosclerosis, the use of natural products stands out. Natural compounds have been applied since ancient times and remain an important therapeutic resource around the world. Despite widespread use, many natural compounds have not experienced careful scientific investigation, whether they are studies of efficacy, toxicity, or drug-to-drug interactions. In addition, there are continued efforts to discover new therapeutic options for the prevention and treatment of arteriosclerosis and related disorders.

In this Special Issue, we would like to invite investigators to submit preclinical or clinical studies focusing on the potential of natural products for the prevention and treatment of arteriosclerosis and related disorders. We will consider both original research and review articles.

Potential topics include but are not limited to the following:

  • The effect of natural products on endothelial function, vascular inflammation, and vascular redox states
  • Isolation and characterization of natural products with cardioprotective effects
  • Plant-derived medicines in the regulation of vascular tone
  • Natural products useful in the treatment of dyslipidemia
  • Preclinical and clinical trials of natural products as anti-atherosclerotic agents
  • Efficacy and safety of natural products for the prevention and treatment of arteriosclerosis and related disorders
  • Mechanisms of traditional drugs based on omics strategies with cardioprotective effects
  • Systematic reviews of natural products with cardioprotective effects focused on endothelial function and/or arteriosclerosis
  • Toxicological effects of natural products related to endothelial function and arteriosclerosis
  • Synergistic effects of drugs and natural products on cardiovascular protection

Articles

  • Special Issue
  • - Volume 2022
  • - Article ID 3311228
  • - Review Article

Vascular Protective Effect and Its Possible Mechanism of Action on Selected Active Phytocompounds: A Review

Nur Aqilah Kamaruddin | Muhammad Nazrul Hakim Abdullah | ... | Yoke Keong Yong
  • Special Issue
  • - Volume 2022
  • - Article ID 8738435
  • - Research Article

Protective Effects of Alternanthera sessilis Ethanolic Extract against TNF-α or H2O2-Induced Endothelial Activation in Human Aortic Endothelial Cells

Nur Nadia Mohd Razali | Soek Sin Teh | ... | Lai Yen Fong
  • Special Issue
  • - Volume 2022
  • - Article ID 4560607
  • - Research Article

Boldine, an Alkaloid from Peumus boldus Molina, Induces Endothelium-Dependent Vasodilation in the Perfused Rat Kidney: Involvement of Nitric Oxide and Small-Conductance Ca2+-Activated K+ Channel

Priscila de Souza | Rita de Cássia Vilhena da Silva | ... | Arquimedes Gasparotto Junior
  • Special Issue
  • - Volume 2022
  • - Article ID 2671343
  • - Research Article

The Improvement of Cardiac and Endothelial Functions of Xue-Fu-Zhu-Yu Decoction for Patients with Acute Coronary Syndrome: A Meta-Analysis of Randomized Controlled Trials

Shiqi Chen | Xiaoxiao Wu | ... | Yahong Wang
  • Special Issue
  • - Volume 2021
  • - Article ID 4010607
  • - Review Article

Atheroprotective Effects and Mechanisms of Postmarketing Chinese Patent Formulas in Atherosclerosis Models: A Systematic Review

Shiqi Chen | Xiaoxiao Wu | ... | Mingjing Zhao
  • Special Issue
  • - Volume 2021
  • - Article ID 6704798
  • - Research Article

Network Pharmacology and Molecular Docking-Based Analysis on Bioactive Anticoronary Heart Disease Compounds in Trichosanthes kirilowii Maxim and Bulbus allii Macrostemi

Yi-Ding Yu | Wang-Jun Hou | ... | Yan Li
  • Special Issue
  • - Volume 2021
  • - Article ID 7203934
  • - Research Article

Ethyl Acetate Fraction from Leandra dasytricha (A. Gray) Cong. Leaves Promotes Vasodilatation and Reduces Blood Pressure in Normotensive and Hypertensive Rats

Rita de Cassia Vilhena da Silva | Luísa Nathália Bolda Mariano | ... | Priscila de Souza
  • Special Issue
  • - Volume 2021
  • - Article ID 6580458
  • - Research Article

Multiple Risk Factors for Heart Disease: A Challenge to the Ethnopharmacological Use of Croton urucurana Baill.

Priscila Megda João Job Zago | Gustavo Ratti da Silva | ... | Francislaine Aparecida dos Reis Lívero
  • Special Issue
  • - Volume 2021
  • - Article ID 4471944
  • - Research Article

Efficacy and Safety of Curcumin Supplement on Improvement of Insulin Resistance in People with Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Tianqing Zhang | Qi He | ... | Hengjing Hu
Evidence-Based Complementary and Alternative Medicine
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Article of the Year Award: Outstanding research contributions of 2021, as selected by our Chief Editors. Read the winning articles.