Evidence-Based Complementary and Alternative Medicine

Natural Bioactive Ingredients as Oxidative Medicines with Antimicrobial Activity for Chronic Disease Treatment: from Drug Development to Industrial Production


Publishing date
01 Jan 2022
Status
Closed
Submission deadline
10 Sep 2021

Lead Editor

1Central South University, Changsha, China

2Monash University, Melbourne, Australia

This issue is now closed for submissions.

Natural Bioactive Ingredients as Oxidative Medicines with Antimicrobial Activity for Chronic Disease Treatment: from Drug Development to Industrial Production

This issue is now closed for submissions.

Description

Recently, natural bioactive ingredients of oxidative medicines have been a focus of many studies owing to their low toxicity and side effects as well as their excellent efficacy. Bioactive ingredients are the main components extracted from herbs that have therapeutic properties. Bioactive ingredients have multilevel effects on numerous chronic diseases, such as the treatment of asthma, anti-inflammation, anti-infection, antimicrobial activity, and the treatment of diabetes mellitus. Usually, the bioactive ingredients of conventional oxidative medicines have been divided into six categories consisting of flavonoids, saponins, terpenoids, alkaloids, polysaccharides, and other organic acids. In addition, studies found that curcumin, magnolol, animal protein, photosensitizers, and reactive oxide species with antimicrobial activity have positive effects in chronic disease treatment. Especially, active polyphenol curcumin as a pro-drug via oxidative activation into reactive metabolites showed excellent anti-inflammatory activities and antibacterial activities.

Although considerable efforts have been made to apply these bioactive ingredients to chronic disease treatment, the lack of systematic studies on therapeutic mechanisms of these bioactive ingredients for disease treatment impedes the extensive application of these oxidative medicines in vivo. For example, the bioactivation of curcumin will occur in vitro, while bioactivation is insufficient in vivo. Therefore, the evaluation and design of clinical trials of curcumin and other medicinal polyphenols should be considered. In addition, the functional mechanism of bioactive ingredients must be highlighted in future research. The safety evaluation and bioavailability of bioactive ingredients are also important indexes for the development of oxidative medicines. The physicochemical and biological properties of curcumin and other bioactive ingredients should also be further discussed before their clinical usage. Furthermore, the industrial production of natural bioactive ingredients is still a huge challenge at present.

This Special Issue aims to summarize the knowledge of underlying mechanisms and physicochemical properties of bioactive ingredients in chronic disease treatment and provide a fully integrated, reliable source of information for the clinical application of bioactive ingredients as oxidative medicines. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

  • Therapeutic properties of natural bioactive ingredients
  • Multilevel effects of bioactive ingredients on treatment of chronic disease
  • Application of bioactive ingredients
  • Safety evaluation of bioactive ingredients
  • Bioavailability of natural bioactive ingredients
  • Functional mechanism of bioactive ingredients for disease treatment
  • Synthesized methods and instrumental analysis of natural bioactive ingredients
  • Chemical engineering and industrial production

Articles

  • Special Issue
  • - Volume 2023
  • - Article ID 9874931
  • - Retraction

Retracted: Effect of Xinyi Biyan Pill in Adjuvant Treatment of Patients with Chronic Rhinosinusitis and Its Influence on Serum Inflammatory Factors and Immune Function

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9892460
  • - Retraction

Retracted: Simultaneous Determination of the Five Constituents in Maiwei Dihuang Pills by the HPLC-DAD Method

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9845737
  • - Retraction

Retracted: Effect of Electroacupuncture Combined with Guizhi Gegen Decoction on Cervical Vertigo and Its Influence on TCD of Vertebrobasilar Artery, Blood Rheology Indexes, and Quality of Life

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9873249
  • - Retraction

Retracted: Ulinastatin as an Adjuvant Therapy to Restricting Volumes of Resuscitation Fluid Strategy for Patients with Septic Shock after Initial Management

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9809240
  • - Retraction

Retracted: Preparation of Curcumin Solid Lipid Nanoparticles Loaded with Flower-Shaped Lactose for Lung Inhalation and Preliminary Evaluation of Cytotoxicity In Vitro

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9835432
  • - Retraction

Retracted: Effect of Tongluozhitong Prescription-Assisted Intra-Articular Injection of Sodium Hyaluronate on VAS Score and Knee Lysholm Score in Patients with Knee Osteoarthritis

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9841676
  • - Retraction

Retracted: Study of Scraping with Copper Stone Based on Theory of Midnight-Noon Ebb-Flow in Angina Pectoris with Coronary Heart Disease of Qi Stagnation and Blood Stasis

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9838103
  • - Retraction

Retracted: Analysis of Carbapenemase-Resistant Genotypes of Highly Virulent Klebsiella pneumoniae and Clinical Infection Characteristics of Different MLST Types

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9836509
  • - Retraction

Retracted: Curative Effect of Early Full Nursing Combined with Postdischarge Continuation Nursing on Patients after Craniocerebral Trauma

Evidence-Based Complementary and Alternative Medicine
  • Special Issue
  • - Volume 2023
  • - Article ID 9861684
  • - Retraction

Retracted: Which Plants for What Ailments: A Quantitative Analysis of Medicinal Ethnobotany of Ile-Ife, Osun State, Southwestern Nigeria

Evidence-Based Complementary and Alternative Medicine
Evidence-Based Complementary and Alternative Medicine
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Acceptance rate7%
Submission to final decision145 days
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