Evidence-Based Complementary and Alternative Medicine

Natural Bioactive Ingredients as Oxidative Medicines with Antimicrobial Activity for Chronic Disease Treatment: from Drug Development to Industrial Production


Publishing date
01 Jan 2022
Status
Closed
Submission deadline
10 Sep 2021

Lead Editor

1Central South University, Changsha, China

2Monash University, Melbourne, Australia

This issue is now closed for submissions.
More articles will be published in the near future.

Natural Bioactive Ingredients as Oxidative Medicines with Antimicrobial Activity for Chronic Disease Treatment: from Drug Development to Industrial Production

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Recently, natural bioactive ingredients of oxidative medicines have been a focus of many studies owing to their low toxicity and side effects as well as their excellent efficacy. Bioactive ingredients are the main components extracted from herbs that have therapeutic properties. Bioactive ingredients have multilevel effects on numerous chronic diseases, such as the treatment of asthma, anti-inflammation, anti-infection, antimicrobial activity, and the treatment of diabetes mellitus. Usually, the bioactive ingredients of conventional oxidative medicines have been divided into six categories consisting of flavonoids, saponins, terpenoids, alkaloids, polysaccharides, and other organic acids. In addition, studies found that curcumin, magnolol, animal protein, photosensitizers, and reactive oxide species with antimicrobial activity have positive effects in chronic disease treatment. Especially, active polyphenol curcumin as a pro-drug via oxidative activation into reactive metabolites showed excellent anti-inflammatory activities and antibacterial activities.

Although considerable efforts have been made to apply these bioactive ingredients to chronic disease treatment, the lack of systematic studies on therapeutic mechanisms of these bioactive ingredients for disease treatment impedes the extensive application of these oxidative medicines in vivo. For example, the bioactivation of curcumin will occur in vitro, while bioactivation is insufficient in vivo. Therefore, the evaluation and design of clinical trials of curcumin and other medicinal polyphenols should be considered. In addition, the functional mechanism of bioactive ingredients must be highlighted in future research. The safety evaluation and bioavailability of bioactive ingredients are also important indexes for the development of oxidative medicines. The physicochemical and biological properties of curcumin and other bioactive ingredients should also be further discussed before their clinical usage. Furthermore, the industrial production of natural bioactive ingredients is still a huge challenge at present.

This Special Issue aims to summarize the knowledge of underlying mechanisms and physicochemical properties of bioactive ingredients in chronic disease treatment and provide a fully integrated, reliable source of information for the clinical application of bioactive ingredients as oxidative medicines. Original research and review articles are welcome.

Potential topics include but are not limited to the following:

  • Therapeutic properties of natural bioactive ingredients
  • Multilevel effects of bioactive ingredients on treatment of chronic disease
  • Application of bioactive ingredients
  • Safety evaluation of bioactive ingredients
  • Bioavailability of natural bioactive ingredients
  • Functional mechanism of bioactive ingredients for disease treatment
  • Synthesized methods and instrumental analysis of natural bioactive ingredients
  • Chemical engineering and industrial production

Articles

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  • - Article ID 4182853
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Clinical Effect of Retroperitoneal Laparoscopic Radical Nephrectomy on Renal Cell Carcinoma, the Influence of Renal Function, and the Influencing Factors of Recurrence

Xiaming Pei | Xiaoxiao Hu | ... | Weiqing Han
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  • - Article ID 6521953
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A Nanoparticle-Conjugated Anti-TBK1 siRNA Induces Autophagy-Related Apoptosis and Enhances cGAS-STING Pathway in GBM Cells

Shengchao Xu | Xi Yan | ... | Chengke Luo
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  • - Volume 2021
  • - Article ID 1303375
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miR-181a Ameliorates the Progression of Myasthenia Gravis by Regulating TRIM9

Qiang Wang | Yunquan Liu | ... | Zhichao Zhou
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  • - Volume 2021
  • - Article ID 2107693
  • - Research Article

Comparative Analysis of Real-Time Dynamic Ultrasound and Magnetic Resonance Imaging in the Diagnosis of Rotator Cuff Tear Injury

Xu Zhang | Xingang Gu | Lei Zhao
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  • - Volume 2021
  • - Article ID 8402517
  • - Review Article

Noscapine, an Emerging Medication for Different Diseases: A Mechanistic Review

Pouria Rahmanian-Devin | Vafa Baradaran Rahimi | ... | Vahid Reza Askari
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  • - Volume 2021
  • - Article ID 7394699
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Serum Levels of HCY, MIF, and hs-CRP Correlate with Glycolipid Metabolism in Adults with Never-Medicated First-Episode Schizophrenia

Xiao Zhong | Qin Ao | Fei Xing
  • Special Issue
  • - Volume 2021
  • - Article ID 4485618
  • - Research Article

Characteristics of the Dynamic Electrocardiogram in the Elderly with Nonvalvular Atrial Fibrillation Combined with Long R-R Intervals

Hongyuan Xu | Jinyi Li | ... | Tao He
  • Special Issue
  • - Volume 2021
  • - Article ID 5023733
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Diagnostic Value of Serum Heparin Binding Protein, Blood Lactic Acid Combined with hs-CRP in Sepsis and Its Relationship with Prognosis

Hongsong Ma | Huasheng Liu | ... | Lieping Huang
  • Special Issue
  • - Volume 2021
  • - Article ID 5754114
  • - Research Article

Influencing Factors and Prevention of Sepsis or Acute Kidney Injury in 85 Patients with Severe Trauma

Hong Zhang | Dan Chen | ... | Bing Li
  • Special Issue
  • - Volume 2021
  • - Article ID 8753076
  • - Research Article

Effect of ERAS Combined with Comfortable Nursing on Quality of Life and Complications in Femoral Neck Fractures of the Aged People

Hu Ping | Xu Ling | ... | Fanghui Dong
Evidence-Based Complementary and Alternative Medicine
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