Chronic inflammation can cause several diseases and conditions, including some cancers, obesity, asthma, rheumatoid arthritis, atherosclerosis, ischemic heart disease, and ulcerative colitis. Despite the fact that multiples of researches were performed on prevention and treatment of inflammation related diseases, the overall incidence has not changed significantly. Moreover, the exact mechanism underlying the process of these diseases still remains hidden. In humans, inflammation is considered a common feature of these diseases, which might be responsible for the dysfunction or dysregulation of specific cells, tissues that contributes to the origin and development of the disease. Due to the fact that chronic inflammation may play crucial roles in disease initiation, a broad spectrum of preclinical and clinical studies have been investigated to reveal the mechanisms of chronic inflammation in the biological system and to develop drugs to overcome inflammation mediated diseases.

Natural products from the herbal remedy, medicinal plants, functional foods, and their constituents have been used for the treatment of various diseases including cancer; in ancient times and recently, increasing emphasis has been focused on the research on traditional medicine: many herbs and medicinal plants. This requires new approaches to overcome inflammation mediated diseases and thus natural products could be an efficacious source for prevention and treatment of these diseases.

In this special issue, we would like to invite investigators to contribute recent original research and review articles both in preclinical and in clinical researches that will strengthen knowledge for therapeutic or preventative utilities of natural products in chronic inflammatory diseases including cancer. Articles will focus on therapeutic or preventative advantages of natural products.

Potential topics include but are not limited to the following:

• Potential effects and mechanism of natural products in treatment or prevention of inflammation-associated diseases
• Identification of molecular targets for natural products in treatment or prevention of inflammation-associated diseases
• Role of natural products from the herbal remedy, medicinal plants, functional foods, and their constituents in chronic diseases-mediated signaling and regulation
• Systemic reviews to evaluate the efficacy and safety of herbal medicines in chronic diseases