Human life expectancy has increased dramatically in recent decades, however, this hasn't been matched by an increase in healthspan. Aging is a physiological process that is mediated by multiple biochemical and genetic processes that are directly related to lifespan and are the driving force behind all age-associated disorders. Several aging mechanisms have been discovered, the most prominent of which are genomic instability, telomere shortening, and cellular senescence. Aging is a risk factor for a wide range of age-related diseases, including neurological diseases, cardiovascular disease, cancer, immune system problems, and musculoskeletal disorders.

Efforts to find medications that increase healthspan by targeting aging etiology are currently a prominent topic in science. Natural bioactive materials hold great promise for the creation of innovative medicinal treatments. Although terrestrial sources have always taken precedence over marine sources, the latter have recently attracted equal attention due to their highly diversified bioactive compounds with distinct chemical structures and bioactivity. Microorganisms, algae, fungus, sponges, cnidarians, mollusks, and other marine life are plentiful in varied chemicals that are largely generated to cope with various environmental stresses. On the other hand, these bioactive molecules have demonstrated a wide range of therapeutic activities, including neuroprotective, antioxidant, anti-inflammatory, immunomodulatory, and antiproliferative effects. Researchers and drug designers have been concentrating their efforts on the identification and development of potential therapeutic leads derived from marine natural materials or their skeletons.

This Special Issue aims to provide new advances in the therapy of aging-related disorders that make use of natural products, bioactive compounds, and natural product-inspired molecules derived from marine sources, as well as their mechanisms of action and operational functions. We welcome original research and review articles.

Potential topics include but are not limited to the following:

• In vitro and in vivo studies of marine natural products
• Isolation and characterization of compounds from marine natural products
• Development of anti-aging products based on marine natural products
• Neuroprotective mechanisms of marine natural products
• Assessment of the efficacy and toxicity of marine natural products
• In silico study of marine natural products