Complementary and alternative medicines (CAMs) have been successfully used as effective and safe treatments in many diseases, such as cardiovascular diseases, metabolic diseases, cancer. Research has shown that CAMs, alone or as an auxiliary therapy, can ameliorate clinical syndromes, postpone or even reverse pathological changes, if under reasonable application. Although clinical efficacy is the main reason that CAMs is able to take its place in modern medicine, the mainstream scientific interpretation and exploration of its efficacy and mechanisms are the keys to its prosperity.

Omics technologies have developed rapidly over the years. Its characteristics, including complexity, multi-dimensions and network interactivity, make innovative tools to illustrate the fundamental concepts and mechanisms of CAMs. Appropriate scientific interpretation of omics technology-related research significantly benefits CAMs-related outcomes.

This Special Issue aims to highlight the latest research using omics technologies, including genomics, transcriptomics, proteomics, metabolomics, or other omics technologies, to explore the fundamental concepts and therapeutic mechanisms of CAMs. Research and review articles demonstrating an existing CAMs-related state or therapy from the perspective of omics technology with solid evidence are particularly encouraged.

Potential topics include but are not limited to the following:

• Exploration of classic or innovative CAMs treatment from the perspective of omics technologies
• Interpretation of basic concepts in CAMs theoretical system, such as blood stasis in traditional Chinese medicine, with omics technologies
• Correlation between pathological changes and omics changes
• Exploration of the therapeutic mechanisms of CAMs from the perspective of omics technology, including herbs, monomers, prescription, patent medicine, and other CAMs treatments
• New understanding of CAMs-related biological and pathological process via omics technology
• The latest omics technology tools and approaches in CAMs study
• The combination of omics technology and other traditional experimental or clinical research approaches in CAMs study
• Identification of objective biomarkers of CAMs via omics technology