Table of Contents Author Guidelines Submit a Manuscript
Emergency Medicine International
Volume 2017, Article ID 4235785, 5 pages
Research Article

Tranexamic Acid (TXA) in Trauma Patients: Barriers to Use among Trauma Surgeons and Emergency Physicians

Department of Emergency Medicine, University of Maryland Shore Regional Health, Easton, MD, USA

Correspondence should be addressed to Abdulaziz Alburaih; moc.liamg@hiarublaziza

Received 17 September 2016; Revised 1 December 2016; Accepted 22 January 2017; Published 20 February 2017

Academic Editor: Joe Nemeth

Copyright © 2017 Abdulaziz Alburaih. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. M. Mannucci and M. Levi, “Lethal injuries and time to death and time to death in a level I trauma center,” Journal of the American College of Surgeons, vol. 186, pp. 528–533, 1998. View at Google Scholar
  2. D. S. Kauvar, R. Lefering, and C. E. Wade, “Impact of hemorrhage on trauma outcome: an overview of epidemiology, clinical presentations, and therapeutic considerations,” Journal of Trauma—Injury, Infection and Critical Care, vol. 60, no. 6, pp. S3–S11, 2006. View at Publisher · View at Google Scholar · View at Scopus
  3. H. C. Tien, F. Spencer, L. N. Tremblay, S. B. Rizoli, and F. D. Brenneman, “Preventable deaths from hemorrhage at a level I Canadian trauma center,” The Journal of Trauma, vol. 62, article 142, 2007. View at Google Scholar
  4. K. Brohi, M. J. Cohen, M. T. Ganter et al., “Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis,” Journal of Trauma - Injury, Infection and Critical Care, vol. 64, no. 5, pp. 1211–1217, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. D. Frith, J. C. Goslings, C. Gaarder et al., “Definition and drivers of acute traumatic coagulopathy: clinical and experimental investigations,” Journal of Thrombosis and Haemostasis, vol. 8, no. 9, pp. 1919–1925, 2010. View at Publisher · View at Google Scholar · View at Scopus
  6. M. Panteli, I. Pountos, and P. V. Giannoudis, “Pharmacological adjuncts to stop bleeding: options and effectiveness,” European Journal of Trauma and Emergency Surgery, vol. 42, no. 3, pp. 303–310, 2016. View at Publisher · View at Google Scholar · View at Scopus
  7. H. Shakur, I. Roberts, R. Bautista et al., “The CRASH-2 Collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial,” The Lancet, vol. 376, no. 9734, pp. 23–32, 2010. View at Google Scholar
  8. I. Roberts and H. Shakur, “The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial,” The Lancet, vol. 377, no. 9771, p. 1096, 2011. View at Google Scholar
  9. J. J. Morrison, J. J. Dubose, T. E. Rasmussen, and M. J. Midwinter, “Military application of tranexamic acid in trauma emergency resuscitation (MATTERs) study,” Archives of Surgery, vol. 147, no. 2, pp. 113–119, 2012. View at Publisher · View at Google Scholar · View at Scopus
  10. S. Binz, J. McCollester, S. Thomas et al., “CRASH-2 study of tranexamic acid to treat bleeding in trauma patients: a controversy fueled by science and social media,” Journal of Blood Transfusion, vol. 2015, Article ID 874920, 12 pages, 2015. View at Publisher · View at Google Scholar
  11. K. Ker, J. Kiriya, P. Perel, P. Edwards, H. Shakur, and I. Roberts, “Avoidable mortality from giving tranexamic acid to bleeding trauma patients: an estimation based on WHO mortality data, a systematic literature review and data from the CRASH-2 trial,” BMC Emergency Medicine, vol. 12, article 3, 2012. View at Publisher · View at Google Scholar · View at Scopus
  12. R. Cole, K. Davenport, K. Willett, and K. Brohi, “Tranexamic Acid use in severely injured civilian patients and the effects in outcomes,” Annals of Surgery, vol. 26, no. 2, pp. 390–394, 2015. View at Google Scholar
  13. K. Ker, P. Edward, P. Patel, H. Shakur, and I. Roberts, “Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis,” British Medical Journal, vol. 344, Article ID e3054, 2012. View at Publisher · View at Google Scholar
  14. J. Cid and M. Lozano, “Tranexamic acid reduces allogeneic red cell transfusions in patients undergoing total knee arthroplasty: results of a meta-analysis of randomized controlled trials,” Transfusion, vol. 45, no. 8, pp. 1302–1307, 2005. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Dalmau, A. Sabaté, F. Acosta et al., “Tranexamic acid reduces red cell transfusion better than ε-aminocaproic acid or placebo in liver transplantation,” Anesthesia and Analgesia, vol. 91, no. 1, pp. 29–34, 2000. View at Google Scholar · View at Scopus
  16. A. Movafegh, L. Eslamian, and A. Dorabadi, “Effect of intravenous tranexamic acid administration on blood loss during and after cesarean delivery,” International Journal of Gynecology and Obstetrics, vol. 115, no. 3, pp. 224–226, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. A. P. Cap, D. G. Baer, J. A. Orman, J. Aden, K. Ryan, and L. H. Blackbourne, “Tranexamic acid for trauma patients: a critical review of the literature,” The Journal of Trauma: Injury, Infection, and Critical Care, vol. 71, no. 1, pp. S9–S14, 2011. View at Publisher · View at Google Scholar
  18. R. S. Jawa, A. Singer, J. E. Mccormack, E. C. Huang, D. N. Rutigliano, and J. A. Vosswinkel, “Tranexamic acid use in united states trauma centers: a national survey,” The American Journal of Surgery, vol. 82, no. 5, pp. 439–447, 2016. View at Google Scholar