Four-Factor Prothrombin Complex Concentrate Reduces Time to Procedure in Vitamin K Antagonist-Treated Patients Experiencing Gastrointestinal Bleeding: A Post Hoc Analysis of Two Randomized Controlled Trials

Table 1

Dose of study treatment per baseline INR.

Baseline INR	4F-PCC dose, IU of factor IX per kg body weight	Plasma dose, mL per kg body weight
2 to <4	25	10
4–6	35	12
>6	50	15

Dose calculation based on 100 kg body weight for patients weighing >100 kg. Maximum dose ≤5000 IU of factor IX (4F-PCC) or ≤1500 mL (plasma). 4F-PCC, four-factor prothrombin complex concentrate; INR, international normalized ratio.