Research Article
Colorectal Perforation in Patients with Connective Tissue Disease
Table 1
Clinicopathological factors in survivors and non-survivors among all patients.
| | | Survivor group (n=98) | Non-survivor group (n=7) | p-value |
| | 1. Patients backgrounds | | | |
| | Age | 62 (18 - 94) | 73 (28 – 95) | 0.09 | | Gender (Male/Female) | 47 (48.0%)/51 (52.0%) | 4 (57.1%)/3 (42.9%) | 0.71 | | Preoperative comorbidity † | | | | | Neurological disease (+/-) | 11 (11.2%)/87 (88.8%) | 1 (14.3%)/6 (85.7%) | 0.58 | | Cardiovascular disease (+/-) | 14 (14.3%)/84 (85.7%) | 0 (0%)/7 (100%) | 0.59 | | Respiratory disease (+/-) | 12 (12.2%)/86 (87.8%) | 0 (0%)/7 (100%) | 1.00 | | Gastroenterological disease (+/-) | 13 (13.3%)/85 (86.7%) | 2 (28.6%)/5 (71.4%) | 0.26 | | Renal disease (+/-) | 10 (10.2%)/88 (89.8%) | 2 (28.6%)/5 (71.4%) | 0.18 | | Hematological disease (+/-) | 3 (3.1%)/95 (96.9%) | 0 (0%)/7 (100%) | 1.00 | | Endocrinological disease (+/-) | 11 (11.2%)/87 (88.8%) | 1 (14.3%)/6 (85.7%) | 0.58 | | Diabetes Mellitus (+/-) | 17 (17.3%)/81 (82.6%) | 3 (42.9%)/4 (57.1%) | 0.13 | | Hypertension (+/-) | 24 (24.5%)/74 (75.5%) | 1 (14.3%)/6 (85.7%) | 1.00 | | Collagen tissue disease (CTD) (+/-) | 21 (21.4%)/77 (78.6%) | 5 (71.4%)/2 (28.6%) | 0.01 |
| | 2. Preoperative status | | | |
| | WBC (/mm3) | 8950 (1000 - 28800) | 7700 (1100 - 37400) | 0.83 | | CRP (mg/dl) | 12.0 (0.1 - 48.9) | 16.9 (3.0 - 32.0) | 0.12 | | SIRS (+/-) | 49 (50.0%)/49 (50.0%) | 5 (71.4%)/2 (28.6%) | 0.44 |
| | 3. Surgical factors | | | |
| The time from onset of symptoms
to operation (> 12hr/≤12hr) | 56 (57.1%)/42 (42.9%) | 3 (42.9%)/4 (57.1%) | 0.70 | | Perforation site (C-T/D-R) | 28 (28.6%)/70 (71.4%) | 1 (14.3%)/6 (85.7%) | 0.67 | | Fecal peritonitis (+/-) | 30 (30.6%)/68 (69.4%) | 5 (71.4%)/2 (28.6%) | 0.04 |
| | 4. Postoperative status | | | |
| | WBC on POD 1 (/mm3) | 8750 (700 - 40300) | 5600 (900 - 39900) | 0.19 | | CRP on POD 1 (mg/dl) | 15.6 (0.2 - 37.8) | 12.7 (6.6 - 27.1) | 0.72 | | Blood culture (+/-) †† | 24 (32.9%)/49 (67.1%) | 1 (20.0%)/4 (80.0%) | 1.00 | | DIC (+/-) | 28 (28.6%)/70 (71.4%) | 5 (71.4%)/2 (28.6%) | 0.03 | | PMX-DHP (+/-) | 34 (34.7%)/64 (65.3%) | 5 (71.4%)/2 (28.6%) | 0.12 |
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Median (min-max), † With some duplications, †† Blood culture was carried out in 78 patients WBC: white blood cell. CRP: C-reactive protein. SIRS: systemic inflammatory response syndrome. C-T: Cecum - Transverse colon. D-R: Descending colon - Rectum. POD: postoperative day. DIC: disseminated intravascular coagulation. PMX-DHP: polymyxin B-immobilized fiber column hemoperfusion. |
