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| | Case 1 | Case 2 | Case 3 | Case 4 |
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| Name | Ye | Zhang | Chen | Li |
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| Age (year) | 6 | 25 | 2 | 50 |
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| Gender | Male | Female | Male | Female |
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| Weight (kg) | 21 | 41 | 12 | 65.9 |
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| Diagnosis | Relapsed and refractory ALL (CR) | Hemophagocytic syndrome (NR) | Acute monocytic leukemia (CR) | Multiple myeloma |
|
| Underlying disease | None | None | None | None |
|
| Treatment before HSCT | Multiple chemotherapy; CAR-T | Multiple chemotherapy | Multiple chemotherapy | Multiple chemotherapy |
|
| EBMT score | 3 | 4 | 2 | — |
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| Type of HSCT | Allo-HSCT | Allo-HSCT | UCBT | Auto-HSCT |
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| Source of stem cells and donor | Peripheral blood of HLA-haploidentical related donor (5/10); single cord blood of unrelated donor (7/10) | Peripheral blood of HLA-haploidentical related donor (5/10); single cord blood of unrelated donor (5/10) | Single cord blood of unrelated donor (7/10) | Peripheral blood |
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| Intensity of conditioning | Intensified myeloablative conditioning | Intensified myeloablative conditioning | Intensified myeloablative conditioning | Myeloablative conditioning (CBV) |
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| Had PICC device | Yes | Yes | Yes | Yes |
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| Pre-HSCT rectal swab | MDRGNB repeatedly (CRE). Day –5: CRE | Negative | Day –11: Enterococcus faecalis (sensitive) | Negative |
|
| Post-HSCT rectal swab | Day +4: CRE
Day +42: CRE
Day +46: CRE | Day +10: CRE | Day +7: CRE | Day +1: CRKp
Day +9: CRKp |
|
| Duration of neutropenia | — | From day –2 to day +14 (died before engraftment) | From day –4 to day +15 | From day –1 to day +10 |
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| Development of GVHD | Grade IV | None | None | None |
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| MDR bacteria | CRE (Escherichia coli) | CRKP (Klebsiella pneumoniae) | CRE (Escherichia coli) | CRKP (Klebsiella pneumoniae) |
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| Treatment | Combination therapy with two drugs | Combination therapy with three drugs | Combination therapy with four drugs | Combination therapy with four drugs |
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| Outcome | Died from acute GVHD and infection | Died from infection at day +14 | Improved | Improved |
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| Reduction in the number of transplanted T cells in haplo-HSCT | Yes | Yes | Yes | Yes |
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| Perianal mucosal damage before BSI | None | None | Perianal mucosal damage | Perianal mucosal damage |
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