Structural and Functional Analysis of the Complex between Citrate and the Zinc Peptidase Carboxypeptidase A

Table 3

Kinetic parameters of BzlSA and citrate inhibition.

Compound	Type of; inhibition	Substrate	𝐾𝑖 (μM)	Reference
BzlSA	competitive	Hipp-Phe^a	1.1	[43]
	competitive	O-Cl-Phe^b	0.2	[44]
	competitive	N-Ac-PSP^c	0.51–0.61	[49]
	competitive	AAFP^d	0.52	This work
citrate	competitive	AAFP^d	5,000	This work

Notes: ^aHippuryl-L-phenylalanine.
^bO-(trans-p-chlorocinnamoyl)-L-β-phenylacetate.
^cN-acetyl-phenylalanyl-3-thiaphenylalanine.
^dN-(4-methoxyphenylazoformyl)-L-phenylalanine.