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Enzyme Research
Volume 2011, Article ID 194857, 5 pages
Review Article

Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target

1Department of Therapy Monitoring and Pharmacogenetics, Medical University of Gdańsk, Debinki 7, 80-211 Gdańsk, Poland
2Laboratory of Molecular and Cellular Nephrology, Mossakowski Medical Research Center, Polish Academy of Sciences, 80-211 Gdańsk, Poland

Received 29 August 2010; Accepted 12 January 2011

Academic Editor: Jun-Mo Yang

Copyright © 2011 Maciej Jankowski. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Autotaxin (ATX) is an extracellular lysophospholipase D (lysoPLD) released from normal cells and cancer cells. Activity of ATX is detected in various biological fluids. The lysophosphatidic acid (LPA) is the main product of ATX. LPA acting through specific G protein-coupled receptors (LPA1-LPA6) affects immunological response, normal development, and malignant tumors' formation and progression. In this review, the impact of autotoxin on biology of melanoma cells and potential treatment is discussed.