Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target

<table>A proposal role for LPA receptors during melanoma progression. LPA receptors activation in melanoma cells leads to p21-activated kinase (PAK) and focal adhesion kinase (FAK) and to the activation of phosphoinositide 3-kinase/Akt-kinase and urokinase-type plasminogen activator (UPA). Finally, the melanoma cells express the metastatic phenotype.</table>

Enzyme Research

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Figure 3: Autotaxin: Its Role in Biology of Melanoma Cells and as a Pharmacological Target 