Therapeutic Implications of Targeting AKT Signaling  in Melanoma

<table>PTEN (EC number: 3.1.3.67) regulates Akt signaling in melanomas.  Isogenic UACC 903 cell lines expressing (29A, 36A, 37A) or not expressing (parental UACC 903, revertant 36A-R1, 36A-R2) PTEN were treated with 1 <i>μ</i>M staurosporine for 4 h and cell lysates analyzed for the expression of pAkt, pPRAS40, and cleaved caspase-3.  The data demonstrates that PTEN null cell lines express high pAkt, pPRAS40, and decreased cleaved caspase-3 fragments compared to cells harboring PTEN, indicating that PTEN sensitizes melanoma cells to chemotherapeutic agents [<a href="/journals/er/2011/327923/#B23">21</a>].</table>

Enzyme Research

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Figure 1

Figure 1: Therapeutic Implications of Targeting AKT Signaling  in Melanoma 