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Enzyme Research
Volume 2011, Article ID 720985, 18 pages
Research Article

Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity

1Growth Control and Differentiation Program, Trescowthick Research Laboratories, Peter MacCallum Cancer Centre, Melbourne, VIC 8006, Australia
2Cancer Genomics Genetics Laboratory, Peter MacCallum Cancer Centre, East Melbourne, VIC 8006, Australia
3Cephalon Australia Pty Ltd., Parkville, VIC 3052, Australia
4Department of Biochemistry and Molecular Biology, University of Melbourne, Melbourne, VIC 3010, Australia
5Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3168, Australia

Received 7 March 2011; Revised 8 June 2011; Accepted 9 June 2011

Academic Editor: Heung Chin Cheng

Copyright © 2011 Rachel S. Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Supplementary Material

Supplementary material containing Supplementary Material and Methods, one Supplementary Table of the antibodies used in the study and three Supplementary Figures is available online at dois 10.4061/2011/720985.

  1. Supplementary Material
  2. Supplementary Material