A Guided Tour of the Structural Biology of Gaucher Disease: Acid-β-Glucosidase and Saposin C
Figure 5
Loop 1 extended and helical conformations: surface view. (a) Extended conformation, overlay of sulfate-bound and glycerol-bound coordinates in this region. (b) Extended conformation found for N370S-mutant GCase (PDB code 3KE0). (c) Helical conformation depicted using coordinates of IFG-bound GCase. Dashed lines are as in Figure 3.
