Review Article

Mode of Action of Lactoperoxidase as Related to Its Antimicrobial Activity: A Review

Figure 6

Illustration of the cofactor role of SCN or I. When the necessary conditions are fulfilled, that is, (i) no substrate competitor for SCN or I for binding to lactoperoxidase, (ii) enough peroxidase, H2O2 and SCN or I, (iii) enough R-SH, and (iv) no incorporation of SCN or I in stable byproducts, the quantity of OSCN or OI produced depends only on the amount of H2O2. SCN: thiocyanate; I: iodide; H2O2: hydrogen peroxide; LPO: lactoperoxidase; R-SH: peptide or protein with a thiol moiety; R-S-SCN or R-S-I sulfenyl thiocyanate or iodide; R-SOH: sulfenic acid; OSCN: hypothiocyanite; and OI: hypoiodite.
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