Table of Contents Author Guidelines Submit a Manuscript
Enzyme Research
Volume 2016, Article ID 9526593, 6 pages
http://dx.doi.org/10.1155/2016/9526593
Research Article

Diagnostic Value of Adenosine Deaminase and Its Isoforms in Type II Diabetes Mellitus

1Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
2Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
3Department of Biochemistry, Pasteur Institute of Iran, Tehran, Iran

Received 14 June 2016; Revised 14 August 2016; Accepted 1 November 2016

Academic Editor: Ali-Akbar Saboury

Copyright © 2016 Bagher Larijani et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background and Aims. In the present study, we have investigated the activity of adenosine deaminase (ADA) as a diagnostic marker in type 2 (or II) diabetes mellitus (T2DM). Design and Methods. The deaminase activity of ADA1 and ADA2 was determined in serum from 33 patients with type 2 (or II) diabetes mellitus and 35 healthy controls. We also determined the proportion of glycated hemoglobin (HbA1c). Results. Our results showed significant differences between total serum ADA (tADA) and ADA2 activities in the diabetic groups with HbA1c < 8 (%) and HbA1c ≥ 8 (%) with respect to the values in healthy individuals (). ADA2 activity in patients with high HbA1c was found to be much higher than that in patients with low HbA1c (). In addition, total ADA activity showed a significant correlation with HbA1c (, ). Conclusions. Total serum ADA activity, specially that due to ADA2, could be useful test for the diagnosis of type 2 (or II) diabetes mellitus.