Enzyme Research

Skin Diseases-Related Enzymes: Mechanisms and Clinical Applications


Publishing date
15 Aug 2011
Status
Published
Submission deadline
15 Feb 2011

Lead Editor

1Zhejiang Provincial Key Laboratory of Applied Enzymology, Yangtze Delta Region Institute of Tsinghua University, Jiaxing 314006, China

2Department of Dermatology, Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul 135-710, Korea

3Department of Environmental Health, School of Public Health and Tropical Medicine, Southern Medical University, Guangzhou 510515, China


Skin Diseases-Related Enzymes: Mechanisms and Clinical Applications

Description

There are higher numbers of known diseases of the skin than any other organ system due to the fact that skin is the first defense system against the external environment and it primarily responses to the various outer challenges. Studies on the skin diseases-associated enzymes are therefore important to understand the complex nature of defense mechanisms and various pathogeneses. With the efforts of researchers, several important diseases-associated enzymes have been gradually revealed and now more than ever, the rapid developments of high-throughput based-technologies in OMICS (such as proteomics and genomics as well as bioinformatics) have enabled researchers to understand diseases and diseases-associated enzymes. New methods and technologies will be important to gain more insight into the complex pathogenesis of cutaneous diseases and to develop effective and precise therapeutic strategies.

We are particularly interested in articles regarding the roles of enzymes in major skin diseases such as atopic dermatitis, psoriasis, pigment disorders, acne, hair loss, and skin cancers. We invite investigators to contribute original research articles and short communications as well as review articles that will provide insights into the roles of enzymes in skin diseases.

Potential topics include, but are not limited to:

  • Latest genetic studies: mutation and SNP analyses for the enzyme of interest
  • Gel-based or nongel-based proteomic findings of enzymes in skin diseases
  • Computational simulations and interactomics for the novel enzyme
  • Molecular functional studies for the novel enzyme
  • Role of enzymes in the pathogeneses of skin disorders with respect to enzymology
  • Kinetics, thermodynamics, and folding studies
  • Clinical case report for the newly detected enzyme
  • Medicinal mechanisms for activation or inhibition of the target enzymes
  • Clinical trials for treating patients

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/er/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 464507
  • - Editorial

Skin Diseases-Related Enzymes: Mechanisms and Clinical Applications

Yong-Doo Park | Jun-Mo Yang | Zhi-Rong Lü
  • Special Issue
  • - Volume 2011
  • - Article ID 387176
  • - Review Article

The Role of Manganese Superoxide Dismutase in Inflammation Defense

Chang Li | Hai-Meng Zhou
  • Special Issue
  • - Volume 2011
  • - Article ID 328249
  • - Research Article

Computational Simulations to Predict Creatine Kinase-Associated Factors: Protein-Protein Interaction Studies of Brain and Muscle Types of Creatine Kinases

Wei-Jiang Hu | Sheng-Mei Zhou | ... | Fan-Guo Meng
  • Special Issue
  • - Volume 2011
  • - Article ID 826784
  • - Research Article

Computational Approach to Identify Enzymes That Are Potential Therapeutic Candidates for Psoriasis

Daeui Park | Hyoung Oh Jeong | ... | Hae Young Chung
  • Special Issue
  • - Volume 2011
  • - Article ID 307464
  • - Research Article

Towards Al3+-Induced Manganese-Containing Superoxide Dismutase Inactivation and Conformational Changes: An Integrating Study with Docking Simulations

Jiang-Liu Yang | Shang-Jun Yin | ... | Zi-Ping Zhang
  • Special Issue
  • - Volume 2011
  • - Article ID 294724
  • - Research Article

Inhibitory Effect of Phthalic Acid on Tyrosinase: The Mixed-Type Inhibition and Docking Simulations

Shang-Jun Yin | Yue-Xiu Si | Guo-Ying Qian
  • Special Issue
  • - Volume 2011
  • - Article ID 409295
  • - Review Article

The Role of Manganese Superoxide Dismutase in Skin Cancer

Delira Robbins | Yunfeng Zhao
  • Special Issue
  • - Volume 2011
  • - Article ID 327923
  • - Review Article

Therapeutic Implications of Targeting AKT Signaling in Melanoma

SubbaRao V. Madhunapantula | Gavin P. Robertson
  • Special Issue
  • - Volume 2011
  • - Article ID 482498
  • - Review Article

The Roles of ADAMs Family Proteinases in Skin Diseases

Masakazu Kawaguchi | Vincent J. Hearing
  • Special Issue
  • - Volume 2011
  • - Article ID 427285
  • - Review Article

Beneficial Regulation of Matrix Metalloproteinases for Skin Health

Neena Philips | Susan Auler | ... | Salvador Gonzalez

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