Enzyme Research

Regulation and Functions of Protein Kinases and Phosphatases


Publishing date
01 Aug 2011
Status
Published
Submission deadline
01 Feb 2011

1Department of Biochemistry and Molecular Biology, Bio21 Institute of Molecular Science and Biotechnology, The University of Melbourne, Parkville, VIC 3010, Australia

2Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong

3Department of Neurology and Neurosurgery, McGill University, Montreal, QC, Canada

4Department of Surgery, The University of Melbourne, Royal Melbourne Hospital, Parkville, VIC 3010, Australia


Regulation and Functions of Protein Kinases and Phosphatases

Description

Protein kinases and phosphatases are involved in all facets of cellular processes ranging from metabolism to neuronal survival. Thus, it is not surprising that aberrant regulation of their activity, subcellular localization, and expression contributes to pathogenesis and progression of many human diseases such as cancer, neurodegeneration, and metabolic diseases. Knowledge of the regulation and structures of a number of protein kinases has led to the development of small molecule inhibitors as therapeutics for cancer treatment. The most notable examples are the small molecule inhibitors of protein kinases that are used as therapeutics for the treatment of chronic myelogenous leukaemia including Imatinib, Nilotinib, and Dasatinib. There is no doubt that further investigations that aim at elucidating the regulation and substrate recognition of protein kinases and phosphatases will benefit the development of therapeutic strategies for the treatment and prevention of many diseases.

We invite researchers to contribute manuscripts documenting the findings of original research and review articles in enzymology of protein kinases and phosphatases. We are particularly interested in articles describing the catalytic and kinetic mechanisms, regulation, substrate recognition and inhibitor designs of protein kinases and phosphatases. Potential topics include, but are not limited to:

  • Identification of protein substrates of eukaryotic and prokaryotic protein kinases and phosphatases
  • Elucidation of the structural basis of substrate specificity of protein kinases and phosphatases
  • Studies of the catalytic and kinetic mechanisms of protein kinases and phosphatases
  • Elucidation of the regulatory and catalytic mechanisms of protein kinases and phosphatases using biophysical approaches such as analytical ultracentrifugation and nuclear magnetic resonance spectroscopy
  • Structural basis of inhibition of protein kinases and phosphatases by small-molecule inhibitors
  • Recent development in the design of chemosensor peptide substrates and biosensors to monitor the activity and subcellular localization of protein kinases and phosphatases in vitro and in cells
  • Recent development in the design of assays for high throughput screening of small-molecule inhibitors of protein kinases and phosphatases

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/er/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 794089
  • - Editorial

Regulation and Function of Protein Kinases and Phosphatases

Heung-Chin Cheng | Robert Z. Qi | ... | Hong-Jian Zhu
  • Special Issue
  • - Volume 2011
  • - Article ID 561841
  • - Review Article

Phosphorylcholine Phosphatase: A Peculiar Enzyme of Pseudomonas aeruginosa

Carlos Eduardo Domenech | Lisandro Horacio Otero | ... | Angela Teresita Lisa
  • Special Issue
  • - Volume 2011
  • - Article ID 329098
  • - Review Article

Protein Kinases and Phosphatases in the Control of Cell Fate

Angela Bononi | Chiara Agnoletto | ... | Paolo Pinton
  • Special Issue
  • - Volume 2011
  • - Article ID 537821
  • - Review Article

Protein Kinase C and Toll-Like Receptor Signaling

Daniel J. Loegering | Michelle R. Lennartz
  • Special Issue
  • - Volume 2011
  • - Article ID 720985
  • - Research Article

Relative Expression Levels Rather Than Specific Activity Plays the Major Role in Determining In Vivo AKT Isoform Substrate Specificity

Rachel S. Lee | Colin M. House | ... | Katherine M. Hannan
  • Special Issue
  • - Volume 2011
  • - Article ID 356093
  • - Review Article

Acid Phosphatases of Budding Yeast as a Model of Choice for Transcription Regulation Research

Elena V. Sambuk | Anastasia Yu. Fizikova | ... | Marina V. Padkina
  • Special Issue
  • - Volume 2011
  • - Article ID 398751
  • - Review Article

Determinants for Substrate Specificity of Protein Phosphatase 2A

Andrew M. Slupe | Ronald A. Merrill | Stefan Strack
  • Special Issue
  • - Volume 2011
  • - Article ID 103980
  • - Review Article

Inorganic Phosphate as an Important Regulator of Phosphatases

Claudia Fernanda Dick | André Luiz Araújo Dos-Santos | José Roberto Meyer-Fernandes
  • Special Issue
  • - Volume 2011
  • - Article ID 896567
  • - Review Article

Control of Genetically Prescribed Protein Tyrosine Kinase Activities by Environment-Linked Redox Reactions

Izumi Nakashima | Yoshiyuki Kawamoto | ... | Masashi Kato
  • Special Issue
  • - Volume 2011
  • - Article ID 523420
  • - Review Article

Canonical and Alternative Pathways in Cyclin-Dependent Kinase 1/Cyclin B Inactivation upon M-Phase Exit in Xenopus laevis Cell-Free Extracts

Jacek Z. Kubiak | Mohammed El Dika

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