Enzyme Research

New Enzymes as Potential Therapeutic Targets for Trypanosomiases and Leishmaniasis


Publishing date
15 Jun 2011
Status
Published
Submission deadline
15 Dec 2010

1Instituto de Investigaciones Medicas Alfredo Lanari, CONICET and Universidad de Buenos Aires, Buenos Aires, Argentina

2Instituto de Ciencias Biomedicas, Universidade de São Paulo, São Paulo, Brazil

3Instituto de Parasitologia y Biomedicina “Lopez-Neyra”, Granada, Spain


New Enzymes as Potential Therapeutic Targets for Trypanosomiases and Leishmaniasis

Description

Infections caused by the protozoan parasites Trypanosoma cruzi, Trypanosoma brucei, and Leishmania spp. are among the most relevant public health problems in the developing countries. Furthermore, climatic changes and migratory fluxes of the human population are broadening the former geographic restrictions of most of these diseases. Only a few therapeutic treatments are available for these infections, and main drawbacks of drugs in use are their low efficiency, high toxicity, and the emergence of strains resistant to available treatments. All these facts make the research on new drug targets and strategies for developing new drug therapeutic strategies a relevant issue.

We invite investigators to contribute original research papers and full-length reviews on the discovery of novel enzyme targets which will contribute to have a picture of the state of the art on trypanosomatid enzymes research oriented to therapeutic applications. The enzymes to be covered include, but are not limited to protein kinases and phosphatases associated to signal transduction and cell cycle, energetic metabolism phosphotransferases (arginine kinase, adenylate kinase, and nucleoside diphosphate kinase), amino acid and fatty acid metabolism, glycosomal enzymes, transsialidases and proteases involved in cell invasion process, polyamines and trypanothione synthesis, detoxification and redox enzymes, purines and pyrimidines metabolism, RNA transsplicing processing, and kinetoplast/nucleus associated enzymes. Potential topics include, but are not limited to:

  • New enzyme drug targets
  • Parasite enzymes/metabolic pathways absent in mammalian hosts
  • In silico prediction of putative enzyme drug targets
  • High-throughput platforms to evaluate new drugs and compound libraries as enzyme inhibitors
  • Genetic and biochemical tools for target validation of enzyme targets

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/er/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 907423
  • - Editorial

New Enzymes as Potential Therapeutic Targets for Trypanosomiases and Leishmaniasis

Claudio Alejandro Pereira | Ariel Mariano Silber | Elena Gonzalez-Rey
  • Special Issue
  • - Volume 2011
  • - Article ID 543912
  • - Research Article

Specific and Nonhomologous Isofunctional Enzymes of the Genetic Information Processing Pathways as Potential Therapeutical Targets for Tritryps

Monete Rajão Gomes | Ana Carolina Ramos Guimarães | Antonio Basílio de Miranda
  • Special Issue
  • - Volume 2011
  • - Article ID 970983
  • - Research Article

Molecular Cloning and Characterization of P4 Nuclease from Leishmania infantum

Safar Farajnia | Leila Rahbarnia | ... | Soheila Montazer Saheb
  • Special Issue
  • - Volume 2011
  • - Article ID 657460
  • - Research Article

Trypanosoma cruzi Coexpressing Ornithine Decarboxylase and Green Fluorescence Proteins as a Tool to Study the Role of Polyamines in Chagas Disease Pathology

Jeremías José Barclay | Luciano Gastón Morosi | ... | Carolina Carrillo
  • Special Issue
  • - Volume 2011
  • - Article ID 415976
  • - Review Article

Biosynthesis of Galactofuranose in Kinetoplastids: Novel Therapeutic Targets for Treating Leishmaniasis and Chagas' Disease

Michelle Oppenheimer | Ana L. Valenciano | Pablo Sobrado
  • Special Issue
  • - Volume 2011
  • - Article ID 518258
  • - Review Article

Trypanosome Prereplication Machinery: A Potential New Target for an Old Problem

Simone Guedes Calderano | Patricia Diogo de Melo Godoy | ... | Maria Carolina Elias
  • Special Issue
  • - Volume 2011
  • - Article ID 230542
  • - Research Article

Identification of a Functional Type IA Topoisomerase, LdTopIIIβ, from Kinetoplastid Parasite Leishmania donovani

Bijoylaxmi Banerjee | Nilkantha Sen | Hemanta K. Majumder
  • Special Issue
  • - Volume 2011
  • - Article ID 648159
  • - Review Article

The Sphingolipid Biosynthetic Pathway Is a Potential Target for Chemotherapy against Chagas Disease

Carolina Macedo Koeller | Norton Heise
  • Special Issue
  • - Volume 2011
  • - Article ID 486928
  • - Research Article

The Involvement of Glutamate Metabolism in the Resistance to Thermal, Nutritional, and Oxidative Stress in Trypanosoma cruzi

Anahí Magdaleno | Brian Suárez Mantilla | ... | Ariel M. Silber
  • Special Issue
  • - Volume 2011
  • - Article ID 873230
  • - Review Article

Role of Heme and Heme-Proteins in Trypanosomatid Essential Metabolic Pathways

Karina E. J. Tripodi | Simón M. Menendez Bravo | Julia A. Cricco

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