Research Article
Efficiency of a Small Size Screening Instrument in Identifying Children with Autism Spectrum Disorders in a Large Population of Twins
Table 4
Discriminative value according to various cutoffs for the total score of questions a–e (score range 0–10 point).
| | = case sample | Sensitivity, % (95% CI) | Specificity, % (95% CI) | CCR, % (95% CI) |
| | All ASD1 () | | | | | cutoff ≥ 1 | 88.0 (80.3–93.4) | 61.7 (60.9–62.4) | 61.8 (61.1–62.6) | | cutoff ≥ 2* | 79.6 (70.8–86.8) | 81.4 (80.7–81.9) | 81.3 (80.7–81.9) | | cutoff ≥ 3 | 68.5 (58.9–77.1) | 90.5 (90.1–91.0) | 90.4 (89.9–90.8) |
| | 299.00 + F84.0 only2 () | | | | | cutoff ≥ 1 | 90.9 (75.7–98.1) | 61.7 (60.9–62.4) | 61.7 (61.0–62.5) | | cutoff ≥ 2 | 90.9 (75.7–98.1) | 81.4 (80.7–81.9) | 81.4 (80.8–82.0) | | cutoff ≥ 3* | 81.8 (64.5–93.0) | 90.5 (90.1–91.0) | 90.5 (90.1–91.0) | | cutoff ≥ 4 | 69.7 (51.3–84.4) | 94.9 (94.6–95.2) | 94.9 (94.5–95.2) |
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1 = 299.00 + F84.0, autism; 299.01 + F84.1, atypical autism; F84.5, Asperger syndrome;
F84.8 and F84.9, pervasive developmental disorder not otherwise specified/other. 2 = autism (299.0 + F84.0),
*: optimal cut-off.
CCR: correct classification rate.
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