Efficiency of a Small Size Screening Instrument in Identifying Children with Autism Spectrum Disorders in a Large Population of Twins
Table 5
Discriminative value according to cutoffs for questions a–e separately (score range 0–2 point each).
= case sample
Sensitivity, % (95% CI)
Specificity, % (95% CI)
CCR, % (95% CI)
Items a
All ASD1 diagnoses ()
cutoff ≥1*
62.9 (52.9–72.1)
95.9 (95.6–96.2)
95.7 (95.3–96.0)
299.0 + F84.0 only2 ()
cutoff ≥1*
78.1 (60.0–90.7)
95.9 (95.6–96.2)
95.8 (95.5–96.1)
Items b
All ASD1 diagnoses ()
cutoff ≥1*
67.6 (57.9–76.3)
73.7 (73.0–74.3)
73.6 (72.9–74.3)
299.0 + F84.0 only2 ()
cutoff ≥1*
69.7 (51.3–84.4)
73.7 (73.0–74.3)
73.6 (73.0–74.3)
Items c
All ASD1 diagnoses ()
cutoff ≥1*
63.9 (54.1–72.9)
94.4 (94.1–94.8)
94.2 (93.9–94.6)
299.00 + F84.0 only2 ()
cutoff ≥1*
78.8 (61.1–91.0)
94.4 (94.1–94.8)
94.4 (94.0–94.7)
Items d
All ASD1 diagnoses ()
cutoff ≥1*
52.4 (42.4–62.2)
86.2 (85.6–86.7)
85.9 (85.4–86.5)
299.00 + F84.0 only2 ()
cutoff ≥1*
60.6 (42.1–77.1)
86.2 (85.6–86.7)
86.1 (85.6–86.6)
Items e
All ASD1 diagnoses ()
cutoff ≥1*
64.8 (55.0–73.8)
82.1 (81.5–82.7)
82.0 (81.4–82.6)
299.00 + F84.0 only2 ()
cutoff ≥1*
84.9 (68.1–94.9)
82.1 (81.5–82.7)
82.1 (81.5–82.7)
Items: a = exhibit strange behaviour; b = exhibit sudden change in mood or feelings; c = cannot get along with others; d = cannot sit still, is restless or hyperactive; e = cannot pay attention for long. 1 = 299.00 + F84.0, autism; 299.01 + F84.1, atypical autism; F84.5, Asperger syndrome; F84.8 and F84.9, pervasive developmental disorder not otherwise specified/other. 2 = Autism (299.00 + F84.0).
*: optimal cutoff. CCR: correct classification rate.
