Review Article

Evolution and Prospects for Intracranial Pharmacotherapy for Refractory Epilepsies: The Subdural Hybrid Neuroprosthesis

Figure 3

The recording/drug delivery unit of the subdural HNP, designed for tests in nonhuman primates. Photograph shows the side of the unit that faces the pia mater. Two fluid inputs (arrowheads) serve to deliver a drug solution (e.g., muscimol) or a flushing fluid (e.g., saline) into each fluid port. Should the tests in nonhuman primates confirm the safety of this unit, it can be readily adapted to human use. Essentially, this is a combination of a commercially available subdural electrode strip by Ad-Tech (Racine, WI) and a custom-designed fluid-port strip by DocXS Bioemdial Products (Ukiah, CA). No other materials than stainless steel and medical grade silicone are used for its construction. Thickness = 1.2 mm.
725696.fig.003