Characterization of the Gene Expression Profile of Human Hippocampus in Mesial Temporal Lobe Epilepsy with Hippocampal Sclerosis
Figure 4
Laser scanning confocal microscopy of P-gp and GFAP expression in MTLE (a–c) and control (d–i) tissue sections. (a–c) High expression of P-gp which appears restricted to the luminal side of microvascular endothelial cells (b, c; arrows) and is not detectable on GFAP-positive astrocytes (a, c). A control capillary (d-f) and a small arteriole (g-i) showing P-gp expression preferentially localized on the endothelial luminal front (e, f, h, i; arrows) and absence of P-gp in the GFAP-positive perivascular astrocytes (d, f, g, i). Note in (h, i) the expression of P-gp on smooth muscle cells (arrowheads). Scale bars: a–f, 10 μm; g-h 20 μm.
