Table of Contents
Epilepsy Research and Treatment
Volume 2011 (2011), Article ID 840616, 5 pages
Review Article

Gamma Knife Radiosurgery for Mesial Temporal Lobe Epilepsy

1Department of Neurological Surgery, University of California at San Francisco, San Francisco, CA 94143, USA
2Department of Neurology, University of Virginia, Charlottesville, VA 22908, USA
3Department of Neurology, University of California at San Francisco, San Francisco, CA 94143, USA

Received 30 June 2011; Revised 30 August 2011; Accepted 6 September 2011

Academic Editor: Giangennaro Coppola

Copyright © 2011 John D. Rolston et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Many patients with mesial temporal lobe epilepsy continue to have seizures despite medical therapy. For these patients, one recourse is surgical resection of the mesial temporal lobe, with its attendant risks. Noninvasive treatment with Gamma Knife radiosurgery is under active investigation as a possible alternative to open surgery. Accumulated evidence from multiple studies shows radiosurgery to be comparable in outcomes to surgical resection. A definitive randomized, controlled trial, the Radiosurgery or Open Surgery for Epilepsy (ROSE) trial, is currently underway, and further investigation of this promising treatment is crucial in our advancement of alternative therapies to treat refractory epilepsy.