Table of Contents
Epilepsy Research and Treatment
Volume 2012, Article ID 103160, 15 pages
Review Article

Neocortical Temporal Lobe Epilepsy

1Division of Neurology, University of Toronto, Toronto, ON, Canada
2Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada
3Department of Medical Imaging, University of Western Ontario, London, ON, Canada
4Department of Medical Biophysics, University of Western Ontario, London, ON, Canada
5Department of Psychology, University of Western Ontario, London, ON, Canada
6London Health Sciences Centre, B10-110, London, ON, Canada N6A 5A5

Received 20 May 2011; Revised 4 January 2012; Accepted 22 May 2012

Academic Editor: Warren T. Blume

Copyright © 2012 Eduard Bercovici et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Complex partial seizures (CPSs) can present with various semiologies, while mesial temporal lobe epilepsy (mTLE) is a well-recognized cause of CPS, neocortical temporal lobe epilepsy (nTLE) albeit being less common is increasingly recognized as separate disease entity. Differentiating the two remains a challenge for epileptologists as many symptoms overlap due to reciprocal connections between the neocortical and the mesial temporal regions. Various studies have attempted to correctly localize the seizure focus in nTLE as patients with this disorder may benefit from surgery. While earlier work predicted poor outcomes in this population, recent work challenges those ideas yielding good outcomes in part due to better localization using improved anatomical and functional techniques. This paper provides a comprehensive review of the diagnostic workup, particularly the application of recent advances in electroencephalography and functional brain imaging, in neocortical temporal lobe epilepsy.