Table of Contents
Epilepsy Research and Treatment
Volume 2012, Article ID 205131, 8 pages
Research Article

Epileptic Encephalopathies in Adults and Childhood

1Neurology Department, American Hospital, 34365 Istanbul, Turkey
2Neurosurgery Department, Koc University School of Medicine, Rumelifeneri Yolu Sarıyer, Istanbul 34450, Turkey

Received 13 January 2012; Revised 28 March 2012; Accepted 10 June 2012

Academic Editor: Nicola Specchio

Copyright © 2012 Zekiye Kural and Ali Fahir Ozer. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Epileptic encephalopathies are motor-mental retardations or cognitive disorders secondary to epileptic seizures or epileptiform activities. Encephalopaties due to brain damage, medications, or systemic diseases are generally not in the scope of this definition, but they may rarely accompany the condition. Appropriate differential diagnosis of epileptic seizures as well as subclinical electroencephalographic discharges are crucial for management of seizures and epileptiform discharges and relative regression of cognitive deterioration in long-term followup. Proper antiepileptic drug, hormonal treatment, or i.v. immunoglobulin choice play major role in prognosis. In this paper, we evaluated the current treatment approaches by reviewing clinical electrophysiological characteristics of epileptic encephalopathies.