TY - JOUR A2 - Mirsattari, Seyed M. AU - Sanon, Nathalie T. AU - Desgent, Sébastien AU - Carmant, Lionel PY - 2012 DA - 2012/04/23 TI - Atypical Febrile Seizures, Mesial Temporal Lobe Epilepsy, and Dual Pathology SP - 342928 VL - 2012 AB - Febrile seizures occurring in the neonatal period, especially when prolonged, are thought to be involved in the later development of mesial temporal lobe epilepsy (mTLE) in children. The presence of an often undetected, underlying cortical malformation has also been reported to be implicated in the epileptogenesis process following febrile seizures. This paper highlights some of the various animal models of febrile seizures and of cortical malformation and portrays a two-hit model that efficiently mimics these two insults and leads to spontaneous recurrent seizures in adult rats. Potential mechanisms are further proposed to explain how these two insults may each, or together, contribute to network hyperexcitability and epileptogenesis. Finally the clinical relevance of the two-hit model is briefly discussed in light of a therapeutic and preventive approach to mTLE. SN - 2090-1348 UR - https://doi.org/10.1155/2012/342928 DO - 10.1155/2012/342928 JF - Epilepsy Research and Treatment PB - Hindawi Publishing Corporation KW - ER -