Table of Contents Author Guidelines Submit a Manuscript
Epilepsy Research and Treatment
Volume 2012 (2012), Article ID 342928, 9 pages
Review Article

Atypical Febrile Seizures, Mesial Temporal Lobe Epilepsy, and Dual Pathology

1Département de Pédiatrie, Centre de Recherche du Centre Hospitalier Universitaire (CHU) Sainte-Justine, Université de Montréal, Montréal, QC, Canada H3T 1C5
2Département de Physiologie, Faculté de Médecine, Université de Montréal, Montréal, QC, Canada H3C 3J7

Received 25 December 2011; Revised 2 February 2012; Accepted 7 February 2012

Academic Editor: Seyed M. Mirsattari

Copyright © 2012 Nathalie T. Sanon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Febrile seizures occurring in the neonatal period, especially when prolonged, are thought to be involved in the later development of mesial temporal lobe epilepsy (mTLE) in children. The presence of an often undetected, underlying cortical malformation has also been reported to be implicated in the epileptogenesis process following febrile seizures. This paper highlights some of the various animal models of febrile seizures and of cortical malformation and portrays a two-hit model that efficiently mimics these two insults and leads to spontaneous recurrent seizures in adult rats. Potential mechanisms are further proposed to explain how these two insults may each, or together, contribute to network hyperexcitability and epileptogenesis. Finally the clinical relevance of the two-hit model is briefly discussed in light of a therapeutic and preventive approach to mTLE.