Table of Contents
Epilepsy Research and Treatment
Volume 2012, Article ID 385626, 10 pages
Review Article

Spontaneous EEG-Functional MRI in Mesial Temporal Lobe Epilepsy: Implications for the Neural Correlates of Consciousness

1Department of Psychology, Vanderbilt University, Nashville, 37211 TN, USA
2Department of Psychology, University of Western Ontario, London, ON, Canada N6A 5A5
3Department of Physiology and Pharmacology, University of Western Ontario, London, ON, Canada N6A 5A5
4Department of Clinical Neurological Sciences, University of Western Ontario, London, ON, Canada N6A 5A5
5Department of Medical Biophysics, University of Western Ontario, London, ON, Canada N6A 5A5

Received 20 September 2011; Revised 21 November 2011; Accepted 19 December 2011

Academic Editor: Warren T. Blume

Copyright © 2012 Zheng Wang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The combination of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) has been shown to have great potential for providing a greater understanding of normal and diseased states in both human and animal studies. Simultaneous EEG-fMRI is particularly well suited for the study of epilepsy in that it may reveal the neurobiology of ictal and interictal epileptiform discharges and noninvasively localize epileptogenic foci. Spontaneous, coherent fluctuations of neuronal activity and the coupled hemodynamic responses have also been shown to provide diagnostic markers of disease, extending our understanding of intrinsically structured ongoing brain activity. Following a short summary of the hardware and software development of simultaneous EEG-fMRI, this paper reviews a unified framework of integrating neuronal and hemodynamic processes during epileptic seizures and discusses the role and impact of spontaneous activity in the mesial temporal lobe epilepsies with particular emphasis on the neural and physiological correlates of consciousness.