Table of Contents
Epilepsy Research and Treatment
Volume 2012, Article ID 687219, 12 pages
Review Article

Role of Functional MRI in Presurgical Evaluation of Memory Function in Temporal Lobe Epilepsy

Departments of Clinical Neurological Sciences, Medical Biophysics, Medical Imaging and Psychology, The University of Western Ontario, London, ON, Canada N6A 5A5

Received 16 May 2011; Revised 7 March 2012; Accepted 11 March 2012

Academic Editor: Warren T. Blume

Copyright © 2012 Chusak Limotai and Seyed M. Mirsattari. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Many diagnostic tools have been employed to predict the likelihood of a postoperative memory decline after a standard temporal lobectomy, including the intracarotid amobarbital testing (IAT) or Wada, regarded as the gold standard test for over the past half a century. Functional MRI (fMRI) is also a promising tool in that regard. Its routine use to predict the postoperative memory decline has been limited because of the varied study paradigms, discrepancies in analysis, and interpretation of the results. Based on the existing literatures, fMRI cannot replace IAT for the routine presurgical evaluation of the patients with temporal lobe epilepsy (TLE) yet. Large multicentre studies with a panel of memory test are required to determine the full potential of fMRI and use it reliably to replace IAT in the routine clinical practice. In this paper, we review various aspects of memory fMRI, including the experimental designs, data analysis, and findings.