Table 1: Positive and negative effects of AED’s [36].

Antiepileptic drugNegative psychotropic symptomsPositive psychotropic symptoms

BarbituratesDepression, hyperactivityAnxiolytic, hypnotic
Carbamazepine/
oxcarbazepine
IrritabilityMood stabilizer, antimanic
EthosuximideBehavioral abnormalities, psychosisNone identified
FelbamateDepression, anxiety, irritabilityNone identified
GabapentinBehavioral problems in childrenNone identified
LamotrigineInsomnia, agitationMood stabilizer, antidepressant
LevetiracetamIrritability, emotional labilityPossible antimanic
PhenytoinEncephalopathyPossible antimanic
PregabalinUnknownAnxiolytic
TigabineDepression (nonconvulsive status epilepticus)Possible anxiolytic
TopiramateDepression, psychomotor slowing, psychosisMood stabilizer
ValproateEncephalopathyMood stabilizer
VigabatrinDepression, aggression, psychosisNone identified
ZonisamideAgitation, depression, psychosisPossible antimanic