Depression in Temporal Lobe Epilepsy: A Review of Prevalence, Clinical Features, and Management Considerations

Table 2

Seizure prevalence in psychiatric samples during treatment with antidepressant drugs [36].

Antidepressant	Dosage (mg)	Seizure prevalence (%)
Tricyclic Antidepressants (TCA’s)
Amitriptyline	<200 mg	0.1
	>200 mg	0.6
Imipramine	50–600 mg	<0.1–0.9
Clomipramine	>200 mg	0.5
Tetracyclic Antidepressants
Maprotiline	150–200 mg	0.4
Mirtazepine	30 mg	<0.1
Selective Serotonin Reuptake Inhibitors (SSRI’s)
Fluoxetine	20–60 mg	0.2
Fluvoxamine	<100 mg	0.2
Sertraline	50–100 mg	<0.1
Paroxetine	20–60 mg	0.1
Norepinephrine Dopamine Reuptake Inhibitor (NDRI’s)
	300 mg SR	0.1
Bupropion	300–450 mg IR	0.4
	>450 mg IR	>0.6