Table 3: CYP450 enzymes inhibition and induction by antidepressants and antiepileptic drugs [36].

CYP isoenzymeInhibitorsInducersSubstrates

CYP 1A2FluvoxamineSt. John’s WortAntidepressants
FluoxetineTCA’s
ParoxetineFluvoxamine
Tertiary TCA’sMirtazepine
Duloxetine

CYP 2C9/10FluoxetinePhenobarbitalAntidepressants
FluvoxamineCarbamazepineSertraline
PhenytoinFluoxetine
Amitriptyline
Bupropion
Antiepileptics
Phenytoin

CYP 2C19FluvoxamineCarbamazepineAntidepressants
FluoxetinePhenytoinCitalopram
Escitalopram
Sertraline
Clomipramine
Imipramine
Moclobemide
Antiepileptics
Phenytoin
Mephenytoin
Esobarbital
Mephobarbital
Phenobarbital
Primidone

CYP 2D6FluoxetineAntidepressants
ParoxetineFluoxetine
SertralineFluvoxamine
Secondary TCA’sCitalopram
Escitalopram
Duloxetine
Paroxetine
Venlafaxine
Trazodone
Maprotiline
Mirtazepine
TCA’s

CYP 3A4FluoxetineCarbamazepineAntidepressants
FluvoxamineBarbituratesSertraline
MirtazepinePhenytoinVenlafaxine
St. John’s WortEscitalopram
Mirtazepine
Trazodone
TCA’s
Antiepileptics
Carbamazepine
Zonisamide
Tigabine