Table of Contents
Epilepsy Research and Treatment
Volume 2012, Article ID 849540, 16 pages
Review Article

Temporal Lobe Epilepsy in Children

1Divisions of Epilepsy and Child and Adolescent Neurology, Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA
2Department of Neurology, Mayo Clinic, Rochester, MN 55905, USA

Received 10 June 2011; Accepted 21 August 2011

Academic Editor: Seyed M. Mirsattari

Copyright © 2012 Katherine C. Nickels et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


The temporal lobe is a common focus for epilepsy. Temporal lobe epilepsy in infants and children differs from the relatively homogeneous syndrome seen in adults in several important clinical and pathological ways. Seizure semiology varies by age, and the ictal EEG pattern may be less clear cut than what is seen in adults. Additionally, the occurrence of intractable seizures in the developing brain may impact neurocognitive function remote from the temporal area. While many children will respond favorably to medical therapy, those with focal imaging abnormalities including cortical dysplasia, hippocampal sclerosis, or low-grade tumors are likely to be intractable. Expedient workup and surgical intervention in these medically intractable cases are needed to maximize long-term developmental outcome.