Review Article
Metabolic Causes of Epileptic Encephalopathy
Table 4
Cerebral folate deficiencies.
| ā | Disorder or mechanism | Primary cerebral folate deficiency | Folate receptor FR1 defect due to autoantibodies | Folate receptor FR1 defect due to (FOLR1 gene) mutation |
| Disorders with secondary cerebral folate deficiency | Aicardi-Goutieres syndrome | Alpers syndrome | Isolated Rett syndrome | Kearns-Sayre syndrome | Mitochondrial complex I encephalomyopathy | Valproic acid complications |
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