Table of Contents
Epilepsy Research and Treatment
Volume 2013, Article ID 492524, 7 pages
Review Article

Influence of Sleep and Sleep Deprivation on Ictal and Interictal Epileptiform Activity

Clinical Neurophysiology Unit, Infanta Elena Hospital, 28340 Valdemoro, Madrid, Spain

Received 13 March 2013; Revised 29 May 2013; Accepted 29 May 2013

Academic Editor: Michelangelo Maestri

Copyright © 2013 Antonio Díaz-Negrillo. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Sleep is probably one of the most important physiological factors implicated both in epileptic seizures and interictal epileptiform discharges. The neurophysiology concerning the relationship between sleep and epilepsy is well described in the literature; however, the pathological events that culminate in the seizures are poorly explored. The present paper intends to make a rigorous approach to the main mechanisms involved in this reciprocal relation. Knowledge of sleep and sleep deprivation effects in epilepsy stands as crucial in the understanding of how seizures are produced, their possible lines of treatment, and future research.