Review Article

Diagnosis and Management of Epileptic Encephalopathies in Children

Table 3

Classification of West syndrome.

Structural/metabolic
 Pre-, peri-, and postnatal cerebral ischemia
 Cerebral malformations
 Neuro-infections sequalae
 Neurocutaneous syndromes: tuberous sclerosis, incontinentia pigmenti
 Hypothalamic hamartoma
 Inborn errors of metabolism: biotinidase deficiency and other organic aciduria, phenylketonuria, mitochondrial disorders, Menkes disease, nonketotic hyperglycinemia, and antiquitin deficiency
Genetic
 Genetic: CDKL-5, MeCP 2, ARX, STXBP-1, SPTAN1, and PLC-β1
 Chromosomal disorders: down syndrome, 1p36 deletion, and Pallister-Killian syndrome
Unknown