Table of Contents
Epilepsy Research and Treatment
Volume 2013, Article ID 510529, 8 pages
Review Article

Vitamin-Responsive Epileptic Encephalopathies in Children

1Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
2Department of Neurology, Baylor College of Medicine, Houston, TX 77030, USA
3Texas Children’s Hospital, 6621 Fannin Street, CCC 1250.03, 12th Floor, Houston, TX 77030, USA

Received 29 March 2013; Accepted 18 June 2013

Academic Editor: Luigi Maria Specchio

Copyright © 2013 Satish Agadi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Untreated epileptic encephalopathies in children may potentially have disastrous outcomes. Treatment with antiepileptic drugs (AEDs) often may not control the seizures, and even if they do, this measure is only symptomatic and not specific. It is especially valuable to identify potential underlying conditions that have specific treatments. Only a few conditions have definitive treatments that can potentially modify the natural course of disease. In this paper, we discuss the few such conditions that are responsive to vitamin or vitamin derivatives.