A Clinical-EEG Study of Sleepiness and Psychological Symptoms in Pharmacoresistant Epilepsy Patients Treated with Lacosamide
Figure 1
Power spectrum analysis of EEG. Patients were assessed at t0 and after 6 months (t1). The graph shows absolute power (μV2) calculated on O2-Ref EEG traces. qEEG analysis was performed offline on waking EEG recording obtained from 8 to 9.30 A.M., randomly selecting EEG periods lacking ictal and/or interictal abnormalities, movements artifacts, eye blinking, muscle activity or drowsiness signs. On these EEG parts, we used the fast Fourier transform (FFT), considering 2 minutes of EEG signal, automatically segmented by software into 2.56 s epochs. Analysis was performed for each frequency band: delta [1–4 Hz]; theta [4–8 Hz]; alpha [8–12 Hz], and beta [12–30 Hz]. None of these bands were significantly affected by LCM treatment.
