Table of Contents
Epilepsy Research and Treatment
Volume 2013, Article ID 629469, 9 pages
Review Article

Excessive Daytime Sleepiness and Epilepsy: A Systematic Review

1Riosono Sleep Disorders Clinic, Rua Siqueira Campos 53 Sala 1104, Copacabana, 22031-070 Rio de Janeiro, RJ, Brazil
2Epilepsy Program, Deolindo Couto Neurology Institute, Universidade Federal do Rio de Janeiro, Av. Venceslau Braz 95, Botafogo, 22290-140 Rio de Janeiro, RJ, Brazil

Received 17 February 2013; Accepted 10 September 2013

Academic Editor: Raffaele Manni

Copyright © 2013 Andre S. Giorelli et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Sleep complaints are common in patients with epilepsy (PWE). Excessive daytime sleepiness (EDS) is one of the most reported complaints and its impact is still a matter of debate. Objective. Evaluate the relationship between EDS and epilepsy, with emphasis on prevalence, assessment, and causes. Methods. A systematic review on PubMed database in the last 10 years (2002 to 2012). The search returned 53 articles and 34 were considered relevant. After citation analysis, 3 more articles were included. Results. Most studies were cross-sectional and questionnaire based. 14 papers addressed EDS as the primary endpoint. 14 adult and 3 children studies used subjective and objective analysis as methodology. The number of studies increased throughout the decade, with 21 in the last 5 years. Adult studies represent almost three times the number of children studies. EDS prevalence in PWE varies from 10 to 47.5%. Prevalence was higher in developing countries. Conclusion. EDS seems to be related more frequently to undiagnosed sleep disorders than to epilepsy-related factors, and although it affects the quality of life of PWE, it can be improved by treating comorbid primary sleep disorders.