Epilepsy Research and Treatment / 2013 / Article / Tab 3

Review Article

Temporal Lobe Resective Surgery for Medically Intractable Epilepsy: A Review of Complications and Side Effects

Table 3

Synopsis of data of adult temporal lobe epilepsy surgical series and their reported surgical complications.

Series/year of publicationStudy characteristicsNumber of ptsSurgical procedureMortalityMean followupSeizure-free outcomeComplicationsCumulative complication rate*Behavioral/
cognitive/psychiatric
complications

Wiebe et al.,
2001 [1]
Prospective40ATL + AH0%12 months54%None5%5% memory deficits

Cohen-Gadol et al.,
2003 [33]
Prospective47ATL + AH0%6 monthsN/ADiplopia: 19%
VFDs: 69%
88%N/A

Oertel et al.,
2004 [31]
Prospective60Transcortical selective AH0%N/AN/AHemiparesis: 5%
Aphasia: 1.7%
C.N. palsy: 5%
Infections: 1.7%
13.4%N/A

Grivas et al.,
2006 [26]
Retrospective52AH,
lesionectomy + AH
0%33 months71%Hemiparesis: 3.8%
Aphasia: 3.8%
C.N. palsy: 5.8%
VFDs: 5.8%
Hematomas: 3.8%
Pneumonia: 1.9%
Pulmonary embolism: 1.9%
53.4%Decline in neuropsychological status: 26.5% (Verbal memory decline in 29.4%, visual memory decline in 32.4%)

Sindou et al.,
2006 [17]
Retrospective100Tailored ATL + AH0%53 months85%Hemiparesis: 2%
C.N. palsy: 5%
Hydrocephalus: 2%
Meningitis: 3%
Hematomas: 3%
Pulmonary embolism: 1%
19%Permanent neuropsychological impairment: 3%

Roberti et al.,
2007 [15]
Retrospective42Tailored ATL + AH0%60 months64%Frontal branch of facial n. palsy: 2.4%
Bone flap reabsorption: 2.3%
4.7%N/A

Acar et al.,
2008 [24]
Retrospective39Transcortical selective AH0%25.9 months82%Hemiparesis: 2.6%
Dysphasia: 7.7%
VFDs: 10.3%
C.N. palsy: 2.6%
Hemotympanum: 2.6%
Frontal branch of facial n. palsy: 2.6%
33.5%Memory difficulties: 5.1%

Elsharkawy et al.,
2009 [25]
Retrospective483ATL + AH0%2 years72.3%Permanent deficits: 2.3%
Temporary deficits: 2.3%
5%N/A

Heller et al.,
2009 [28]
Retrospective55Tailored ATL + AH0%N/AN/AHemiparesis: 1.8%
Stroke: 5.5%
VFDs: 1.8%
Hematomas/hygromas: 3.6%
Meningitis: 1.8%
Deep venous thrombosis: 1.8%
16.3%N/A

Ipekdal et al.,
2011 [5]
Retrospective58ATL + AH0%N/AN/AStroke: 1.7%
Frontal branch of Facial n. palsy: 1.7%
Infections: 4.7%
Subdural effusion: 1.7%
14.9%Psychosis: 1.7%
Depression: 1.7%
Anxiety disorders: 1.7%

Falowski et al.,
2012 [4]
Retrospective222Tailored AH0%5.4 years70%Dysphasia: 0.9%
Infections: 1.4%
Deep venous thrombosis: 0.9%
3.2%N/A

This rate includes the behavioral/cognitive/psychiatric complications. ATL: anterior temporal lobectomy; AH: amygdalohippocampectomy; VFDs: visual field deficits; C.N.: cranial nerve.

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