Table of Contents
Epilepsy Research and Treatment
Volume 2015 (2015), Article ID 415082, 6 pages
http://dx.doi.org/10.1155/2015/415082
Research Article

Efficacy and Safety of Levetiracetam and Carbamazepine as Monotherapy in Partial Seizures

1Cipla Ltd, 117/1, Anjanadri, Pantharapalya, Bangalore 560039, India
2Department of Pharmacology, Vydehi Institute of Medical Sciences and Research Centre, No. 82 EPIP Area, Whitefield, Bangalore 560037, India
3Department of Neurology, Columbia Asia Hospital, Whitefield, Bangalore 560066, India

Received 31 August 2015; Accepted 1 December 2015

Academic Editor: Roy G. Beran

Copyright © 2015 Swaroop Hassan Suresh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Maguire, G. A. Marson, and S. Ramaratnam, “Epilepsy (generalized),” BMJ Clinical Evidence, vol. 2, article 1201, 2012. View at Google Scholar
  2. S. V. Thomas, S. Koshy, C. R. S. Nair, and S. P. Sarma, “Frequent seizures and polytherapy can impair quality of life in persons with epilepsy,” Neurology India, vol. 53, no. 1, pp. 46–50, 2005. View at Publisher · View at Google Scholar · View at Scopus
  3. M. Gourie-Devi, P. Satishchandra, and G. Gururaj, “Epilepsy control program in India: a district model,” Epilepsia, vol. 44, no. 1, pp. 58–62, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Simon, Handbook of Epilepsy Treatment, Wiley-Blackwell, Oxford, UK, 3rd edition, 2010.
  5. R. Surges, R. D. Thijs, H. L. Tan, and J. W. Sander, “Sudden unexpected death in epilepsy: risk factors and potential pathomechanisms,” Nature Reviews Neurology, vol. 5, no. 9, pp. 492–504, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. A. A. Asadi-Pooya and M. R. Sperling, “Clinical features of sudden unexpected death in epilepsy,” Journal of Clinical Neurophysiology, vol. 26, no. 5, pp. 297–301, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. M. A. Stein and A. M. Kanner, “Management of newly diagnosed epilepsy: a practical guide to monotherapy,” Drugs, vol. 69, no. 2, pp. 199–222, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. S. M. LaRoche, “A new look at the second-generation antiepileptic drugs: a decade of experience,” Neurologist, vol. 13, no. 3, pp. 133–139, 2007. View at Publisher · View at Google Scholar · View at Scopus
  9. M. J. Brodie, E. Perucca, P. Ryvlin et al., “Comparison of levetiracetam and controlled release carbamazepine in newly diagnosed epilepsy,” Neurology, vol. 68, pp. 402–408, 2007. View at Google Scholar
  10. S. Perry, P. Holt, and M. Benatar, “Levetiracetam versus carbamazepine monotherapy for partial epilepsy in children less than 16 years of age,” Journal of Child Neurology, vol. 23, no. 5, pp. 515–519, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. J. A. Cramer, K. Perrine, O. Devinsky, and K. Meador, “A brief questionnaire to screen for quality of life in epilepsy: the QOLIE-10,” Epilepsia, vol. 37, no. 6, pp. 577–582, 1996. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Rosenow, C. Schade-Brittinger, N. Burchardi et al., “The LaLiMo trial: lamotrigine compared with levetiracetam in the initial 26 weeks of monotherapy for focal and generalised epilepsy—an open-label, prospective, randomised controlled multicenter study,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 83, no. 11, pp. 1093–1098, 2012. View at Publisher · View at Google Scholar · View at Scopus
  13. E. Trinka, A. G. Marson, W. Van Paesschen et al., “KOMET: an unblinded, randomised, two parallel-group, stratified trial comparing the effectiveness of levetiracetam with controlled-release carbamazepine and extended-release sodium valproate as monotherapy in patients with newly diagnosed epilepsy,” Journal of Neurology, Neurosurgery and Psychiatry, vol. 84, no. 10, pp. 1138–1147, 2013. View at Publisher · View at Google Scholar · View at Scopus
  14. N. Kumar, H. S. Swaroop, A. Chakraborty, and S. Chandran, “Levetiracetam induced acute reversible psychosis in a patient with uncontrolled seizures,” Indian Journal of Pharmacology, vol. 46, no. 5, pp. 560–561, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. A. Aggarwal, D. D. Sharma, R. C. Sharma, and R. Kumar, “Probable psychosis associated with levetiracetam: a case report,” Journal of Neuropsychiatry and Clinical Neurosciences, vol. 23, no. 3, pp. E19–E20, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. C. L. Harden, “Safety profile of levetiracetam,” Epilepsia, vol. 42, no. 4, pp. 36–49, 2001. View at Google Scholar · View at Scopus
  17. T. Keranen and J. Sivenius, “Side effects of carbamazepine, valproate and clonazepam during long-term treatment of epilepsy,” Acta Neurologica Scandinavica, vol. 68, supplement 97, pp. 69–80, 1983. View at Publisher · View at Google Scholar · View at Scopus
  18. B. S. Kang, H. J. Moon, Y.-S. Kim et al., “The long-term efficacy and safety of levetiracetam in a tertiary epilepsy centre,” Epileptic Disorders, vol. 15, no. 3, pp. 302–310, 2013. View at Publisher · View at Google Scholar · View at Scopus