Delays and Factors Related to Cessation of Generalized Convulsive Status Epilepticus

Table 3

(a) Total-time-correlations: correlations between the onset-to-event and onset-to-treatment-response delays, that is, markers for cessation of SE. (b) Chronological correlations: correlations between the onset-to-event delays and event-to-treatment-response delays, that is, markers for cessation of SE.

(a)

Variable	Onset-to-burst-suppression					Onset-to-clinical-seizure-freedom					Onset-to-consciousness
		Coefficient	95% CI (min)	95% CI (max)	value		Coefficient	95% CI (min)	95% CI (max)	value		Coefficient	95% CI (min)	95% CI (max)	value
Onset-to-initial-treatment	28	0.127	−0.299	0.519	0.520	65	0.054	−0.181	0.289	0.668	56	0.017	−0.213	0.254	0.902
Onset-to-first-convulsion-end	29	0.303	−0.093	0.640	0.110	68	0.122	−0.122	0.363	0.321	58	0.107	−0.166	0.367	0.425
Onset-to-alarm	22	0.467	0.036	0.791	0.029	55	0.300	−0.004	0.558	0.026	47	0.010	−0.256	0.288	0.946
Onset-to-diagnosis	29	0.415	0.040	0.691	0.025	68	0.371	0.120	0.587	0.002	59	0.136	−0.111	0.390	0.304
Onset-to-second-stage-medication	30	0.337	−0.080	0.660	0.069	66	0.334	0.087	0.535	0.006	56	0.402	0.165	0.610	0.002
Onset-to-anesthesia	30	0.510	0.132	0.765	0.004	61	0.382	0.098	0.619	0.002	51	0.088	−0.175	0.353	0.540
Onset-to-first-ED	23	0.500	0.091	0.781	0.015	60	0.260	0.019	0.503	0.045	52	0.212	−0.740	0.476	0.131
Onset-to-tertiary-hospital (HUCH)	30	0.538	0.177	0.780	0.002	69	0.334	0.081	0.559	0.005	59	0.207	−0.550	0.448	0.116
Onset-to-EEG	26	0.099	−0.324	0.496	0.632	54	0.470	0.197	0.688	<0.001	46	0.327	0.037	0.568	0.027
Onset-to-EEG-monitoring	30	0.775	0.503	0.929	<0.001	41	0.413	0.096	0.677	0.007	31	0.239	−0.135	0.542	0.194
Onset-to-burst-suppression						30	0.558	0.165	0.857	0.001	21	0.527	0.071	0.815	0.014
Onset-to-clinical-seizure-freedom											59	0.739	0.576	0.850	<0.001

(b)

Variable	Event-to-burst-suppression					Event-to-clinical-seizure freedom					Event-to-consciousness
Onset-to-event		Coefficient	95% CI (min)	95% CI (max)	value		Coefficient	95% CI (min)	95% CI (max)	value		Coefficient	95% CI (min)	95% CI (max)	value
Onset-to-initial-treatment	28	0.005	−0.421	0.412	0.981	65	−0.095	−0.344	0.156	0.453	56	−0.012	−0.237	0.205	0.928
Onset-to-first-convulsion-end	29	0.109	−0.282	0.474	0.573	68	−0.112	−0.360	0.136	0.362	58	0.085	−0.173	0.322	0.528
Onset-to-alarm	22	0.303	−0.176	0.666	0.171	55	0.020	−0.253	0.295	0.883	47	−0.087	−0.364	0.223	0.563
Onset-to-diagnosis	29	0.169	−0.198	0.497	0.382	68	−0.069	−0.321	0.226	0.574	59	0.037	−0.267	0.322	0.783
Onset-to-second-stage-medication	30	0.057	−0.345	0.421	0.765	66	−0.046	−0.323	0.265	0.713	56	0.295	0.039	0.534	0.027
Onset-to-anesthesia	30	−0.152	−0.488	0.175	0.424	61	−0.057	−0.333	0.211	0.662	51	0.025	−0.251	0.330	0.859
Onset-to-first-ED	23	0.343	−0.062	0.732	0.109	60	−0.022	−0.296	0.271	0.870	52	0.101	−0.195	0.385	0.477
Onset-to-tertiary-hospital (HUCH)	30	0.113	−0.247	0.498	0.552	69	−0.037	−0.285	0.195	0.761	59	0.068	−0.220	0.338	0.610
Onset-to-EEG	26	−0.753	−0.914	−0.473	<0.001	54	−0.198	−0.475	0.081	0.152	46	−0.162	−0.420	0.116	0.283
Onset-to-EEG-monitoring	30	−0.183	−0.579	0.278	0.332	41	−0.051	−0.386	0.279	0.752	31	0.101	−0.311	0.459	0.588
Onset-to-burst-suppression						30	0.031	−0.359	0.443	0.872	21	0.584	0.058	0.863
Onset-to-clinical-seizure-freedom											59	0.275	−0.036	0.563	0.035

Spearman’s rho.
Pearson’s rho.